Debra und Angel können den Kühllaster-Killer identifizieren und finden in seinem Wohnwagen jede Menge Spuren. Während das Team den Fahndungserfolgt feiert ist Dexter enttäuscht. Seinen Gegenspieler hatte er sich anders vorgestellt.

Doakes follows Dexter to his next crime scene and shocks him with a revelation about Harry. The Bay Harbor Butcher task force feels they are zeroing in on their man.

Lila Tournay finds Sgt. James Doakes imprisoned in an Everglades cabin and learns from him that her object of affection, Dexter Morgan, is the serial killer known as the "Bay Harbor Butcher". She decides to help Dexter and kills Doakes by setting the cabin on fire. Meanwhile, Dexter's sister Debra questions whether her career is more important than her relationship with FBI Special Agent Frank Lundy.

Dexter angers Miguel when he says no to his latest offer, who's unsure the next target lives up (or down) to Harry's Code. Meanwhile, an elderly, deathly ill Camilla asks Dexter to kill her, insisting she would never ask a friend to do something against his conscience. Also, Rita discovers that Sylvia believes her husband Miguel has had an affair; and Anton is told he is bait to get at Skinner.

Dexter and Arthur find themselves on a collision course, as Debra unearths a shocking long-hidden truth, Rita admits her marriage to Dexter is troubled, and Batista and LaGuerta face the consequences of an ethics breach.

Dexter must make a choice; Quinn stirs up trouble for Dexter but supports Deb.

Dexter is drawn into a precarious situation; Batista discovers an interesting lead; Quinn gets information about Dexter from a questionable source.

Dexter's situation grows desperate when he discovers that Lumen's been set up. Despite knowing he's being baited into a trap, Dexter risks everything to make sure he doesn't fall into the same mistake again. In the Barrel Girls case, Debra lets her personal feelings lead her instincts once she concludes that vigilantes are more than just a theory. Quinn finds himself in a troublesome situation, which only Dexter can help him out of.

Miami Metro sets out to unearth new evidence on a claim from a local convict that he has new information regarding a 15-year-old crime spree; Debra tries to cure Dexter of his killer tendencies.

Dexter enlists Dr. Vogel's help to lure the Brain Surgeon to a location in order to get him on the table. Later, an important person in Dexter's life is murdered before his eyes.

Season 8 and the series conclude with Dexter facing impossible odds. With a hurricane threatening Miami, Dexter becomes determined to end things.