Grissom and Warrick take the case of a young man who is found naked in the desert without an obvious cause of death. Sara gets to find out why the body of a woman who was buried last week is in a dumpster. Catherine and Nick investigate the killing of a school's dean by the school's founder.

The team must investigate the death of a police officer who died during a shootout leaving hundreds of bullets on the crime scene. The case becomes complicated when it turns out that Sofia Curtis and Jim Brass were with the victims during the shootout. When it turns out the officer died from friendly fire, it is up to the team to find out who fired the fatal shot. Meanwhile, Sofia is wondering whether she fired the fatal shot or not. She decides to hide the fact that the officer stepped into her line of fire, afraid it will ruin her career.

The CSIs must investigate when a party girl is injured and killed in a traffic accident.

Three tourists are beat up, badly. One is dead, Alfonzo. Jessica is badly beaten but is still alive. Stanley, the last tourist is saved by Greg who ends up severely hurt in turn and ends up hospitalized after having to make a life altering decision.

The Cadillac of an infamous 1970’s mob boss turns up in a lake, even though he disappeared years ago. A photo of current murder victims also turns up in the car, so the team must determine whether this current murder spree is related to the missing gangster.

Grissom and his team are discouraged when they find a pool of blood as they begin investigating the disappearance of a high school basketball star and his cheerleader girlfriend.Grissom's quip that the young lovers may have run off to Mexico is soon quashed by the discovery of drops of blood by Ryan's vacant parking spot at the school. After finding a letterman jacket and cheerleading sweater in the field house and a pool of Ryan's blood nearby, the team tries to determine what went awry.

After a man is killed in his limousine, Greg finds that the murder victim has ties to the man he had to kill in self-defense. The team finds that the brother is involved in this investigation and has to deal with him and his hostile mother.

The CSI team investigates two unusual cases, one involving the suspicious death of a go-cart racer who took his hobby to the highway and paid the price with his life, and a murder at a hip new restaurant where patrons dine in the dark

The team investigates an underground mob. Warrick ends up becoming the prime suspect in a murder that's related to the mob, and his addiction to pills starts to have a significant impact on his job as a CSI.

The CSI are called to three different crime scenes in one night that are seemingly unrelated, but each case's forensic evidence reveals a common link

A vampire and werewolf convention becomes the center of a murder investigation.

When a blackout cripples the city, the CSIs must revert to old-school methods to solve the case of a missing child.

An inbound plane’s passengers become the victims of an onboard thief, but when one of the passengers is found dead, the petty crime turns into a murder investigation.

The team investigates the cyber-related murder of a prominent casino owner's wife and receive help from the FBI's Cyber Crime Division.