The entire team investigate the abduction of the infant child of a well to do family. Suspicion immediately falls on the child's parents.

The team is investigating the ongoing murders by a signature killer. The killer has some knowledge of forensics and has left little evidence behind. With the investigation somewhat stalled, the sheriff invites the FBI to join the case. This makes Grissom angry and it only gets worse when Sara offers to bait the killer.

Two couples meet in a bar and one of the couples is murdered. When a second couple is murdered in a similar fashion the team suspects a pair of serial killers are on the loose. The case is complicated by leaks to the press and a judge reluctant to issue a warrant. Catherine gets some troubling news about her father's murder trial.

A suspect's infatuation with Catherine results in her taking over a high profile case. The case is a missing woman who aspired to be a showgirl. Sara and Nick are angered since it takes the career making case away from them.