Two brothers, Sam and Dean Winchester, witness their mother's paranormal death as children and grow up trained to fight by a distraught father who wants nothing more then to hunt down the thing that killed his wife. Sam escapes to college to start a new, normal life, but gets pulled back in after Dean shows up on his doorstep to tell him their father is missing.

Following clues from an eerie phone message from him, the boys travel to a small town and encounter a vengeful spirit called the "Woman in White" who then starts to haunt Sam.

Sam is haunted by a vision of a woman trapped in his childhood house and convinces a reluctant Dean that they need to go home. Upon arrival, they meet the woman in Sam's premonition and she reveals that the house is haunted. Looking into their personal history, the brothers discover their father had visited a psychic after their mother's death and they turn to the same woman for answers of their own. Together they discover a malevolent poltergeist has inhabited the house and set out to exorcise it, but are blindsided when another unseen spirit steps in.

Dean is attacked by a Djinn... and finds himself in a new reality where his mother is still alive and a mysterious woman holds the key to everything.

Sam and other "special children" are abducted by the Yellow-Eyed Demon and taken to a ghost town, where the ultimate battle must start.

Dean and Bobby have something frightening locked in Bobby's panic room: Sam, contaminated by demon blood. But as the apocalypse draws nearer, Bobby wants to free Sam to battle on their side.

Ambushed by angry hunters, Sam and Dean are shot and killed and sent to Heaven. Castiel warns Dean that Zachariah is looking for them in Heaven so they need to lay low while searching for an angel named Joshua who can help them since he talks directly to God. While searching for Joshua, the brothers run into some old friends and family members.

Meg kidnaps Sam and Dean and tries to force them to tell her where Crowley is hiding. Sam makes her a deal - they will help her find Crowley if she promises to torture him for information about how to get Sam's soul back. Castiel joins the fight but finds it difficult to work with Meg.

Sam, Dean, Bobby and Castiel track Eve to a small town in Oregon. The guys discover the townspeople have been converted to demons, but surprisingly, they all appear to be dying. When they finally do meet Eve, she decides to torture the brothers by bringing back their mother.

God comes to a decision about Amara that has direct repercussions for Sam and Dean.

Dean is overwhelmed as he comes face to face with his mom, Mary Winchester. Meanwhile, Sam is fighting for his life after Toni, from the Woman of Letters, shot him.

Dean, Castiel and Mary have a lead on Sam and set out to rescue him. Dean is uncomfortable with putting Mary in danger but she insists on going along. Meanwhile, Crowley is tipped off that Lucifer has taken over the body of rock star Vince Vicente.

When a crying baby leads to death in a mysterious abandoned house, Mary, Sam and Dean decide to investigate. Meanwhile, Castiel’s hunt for Lucifer leads him, begrudgingly, to partner up with Crowley.

When hunters gather together to celebrate the life and tragic death of one of their own, Sam, Dean, and Mary must take action when a demon starts picking off hunters one by one.

After being arrested for the attempted assassination of the President of The United States, Sam and Dean must find a way out of an underground, government-run, detention facility in the middle of nowhere. Determined to find her sons, Mary and Castiel seek assistance from an unlikely source.

Mary asks Sam, Dean and Castiel for help on a case she’s working but neglects to mention the British Men of Letters are involved. When Mary is double crossed, everything is revealed.

When Sam and Dean look into a murder at a museum, they learn a ghost from a merchant ship that sunk in 1723 may be at the heart of the mystery. After realizing “The Star” was the same ship that Crowley’s son Gavin McLeod should have been aboard, they enlist help from Rowena to track Gavin down. Kelly Kline, still pregnant with Lucifer’s child, takes refuge with a demon after an angel attempts to kill her.

A chance to take out a nest of vampires backfires when the alpha-vamp shows up and turns the tables on Mary and the British Men of Letters, who are doing their best to recruit Sam and Dean.

Sam and Dean get a lead on Kelly Kline’s whereabouts. Mick drops by the bunker unexpectedly and decides to join the hunt.

Alicia Banes calls Mary for help after her mother, Tasha, goes missing. Sam answers Mary’s phone and he and Dean head out to help Alicia and her twin brother, Max, find their mother who was hunting a powerful witch. Meanwhile, Mary starts to have some doubts about the British Men of Letters.

Sam and Dean are alarmed when they learn hunters are being killed by suspicious “accidents” all over the country. They decide it is best to find Mary and make sure she’s safe. Meanwhile, Toni is back in the states and she and Mary face off.

Caught in a dangerous situation, Sam and Dean only have each other to rely on. Meanwhile, the fight between the American Hunters and the British Hunters comes to a head.

Lucifer battles Sam, Dean and Castiel for control of his unborn child.

Sam and Dean are left to pick up the pieces after the loss of their mother, the demise of Crowley and the heartbreaking death of Castiel. The birth of Jack leaves the Winchester brothers with differing opinions on how to deal with a Nephilim. After being dragged into the breach, Mary must learn to survive Lucifer and an apocalyptic world.

Sam and Dean begin to explore what Jack is capable of doing with his powers. An unexpected visit from Donatello alerts the boys to the fact that Jack will need more protection than the Winchesters can provide. There is a new Prince of Hell in town, Asmodeus, and with Lucifer out of the picture, he sets his sights set on Jack.

Jack, desperate to prove to Sam and Dean that he is good and that he can control his powers, enlists the help of a dreamcatcher named Kaia to help him find Mary Winchester and save her from the alternate universe. However, when plans go awry, the Winchester brothers are the ones who need saving.

Jack and Mary manage to escape Michael’s clutches and end up finding an ally in “apocalyptic world” Bobby Singer. Meanwhile, Sam, Dean and Castiel continue to search for a way to open a breach, not realizing that one of their own may be working against them and costing them precious time.

Gabriel is back and drags Sam and Dean into his plot for revenge on the demigods who sold him to Asmodeus. Meanwhile, Jack's inflating confidence leads to reckless decisions that could put others in harm's way.

Sam, Dean, Castiel and Gabriel must work together if they have any hope of bringing Mary and Jack home. Meanwhile, Rowena’s encounter with Lucifer may alter the outcome of the journey for one of our heroes.

Sam and Dean devise a plan that will save innocent lives. Meanwhile, Jack continues to wrestle with the consequences of his decisions.

Our heroes, Sam and Dean Winchester, continue to be tested in the battle between good and evil, but one impulsive decision could alter the lives of one the brothers forever.

Sam enlists everyone’s help in trying to track down Dean, who can literally be anywhere. Meanwhile, Castiel may be in over his head after meeting up with an unreliable source. After being drained of his grace, Jack is adjusting to life as a human, learning new skills and figuring out how he fits in to this world of hunters.

Sam finds a clue to Dean’s whereabouts, so he, Mary and Bobby set out to investigate. Castiel imparts some sage advice on Jack, who, still desperate to belong, seeks out a familial connection.

After a hunt gone wrong leaves Maggie’s whereabouts unknown, Sam, Dean, Mary and Bobby race to find her, but what they find are their own worst nightmares.

Dean spends some bonding time with Mary and Donna. Nick finally finds the answer he has been searching for. Sam is left to make an unimaginable choice.

Sam and Dean look to occult lore for a solution to their latest problem, but instead of a resolution, they find much more than either of them had anticipated.

Sam and Dean race to help a friend in need. Meanwhile, Mary is concerned for Jack’s well-being, and Castiel enlists help from Jo/Anael to track down a miracle.

Sam and Dean continue to worry about the condition of Jack’s soul.