Pilot episode. After returning to Washington, D.C., renowned forensic anthropologist Dr. Temperance Brennan is called in by FBI Special Agent Seeley Booth to aid an FBI investigation involving a set of bones found hidden in a lake.

A death row inmate asks for Booth's help to prove his innocence before he is scheduled to be executed. Booth agrees and asks Brennan and her team to help him out.

When a woman’s burned body is found in a car with signs that her child was kidnapped, Brennan and Booth suspect the father, Carl Decker. But things get complicated when Decker turns out to be in the Witness Protection program.

Brennan and Booth investigate the origins of a decomposed body that's been found in a local alley and determine it's the remains of a shy teen with an alter ego.

A human finger bone found in the clutches of a drowning victim leads to a search for buried treasure.

The team helps Deputy Director Sam Cullen's daughter, Amy, when she contracts a rare form of lung cancer after receiving a bone graft. Booth and Brennan learn she is not the only victim with this rare form of cancer.