The investigation of the murder of a video-game designer reveals the wealth he accumulated during his career, which makes a suspect out of everyone who was in his inner circle. Meanwhile, "squintern" Jessica sheds light on an educational opportunity; and Brennan and Booth discuss Christine's future.

The case of a maid's death turns out to be a bigger case than originally thought. Tensions are rising between Cam and Brennan.

The team is called in after the remains of a psychology professor are discovered.

On Brennan and Booth’s first official day back at their respective positions at the Jeffersonian and the FBI, things get exciting when remains are found at a fish farm under suspicious conditions, prompting them to investigate. After it’s discovered that someone harvested several of the victim’s internal organs before he was dumped in the water, Angela tracks down the seller and buyer of the organs to try to uncover important details in the case. Meanwhile, Booth readjusts to his position back at the FBI and discovers Aubrey has taken over his old office; Hodgins pushes Angela to showcase her photography work; and Cam struggles with her decision to choose work over her relationship with Arastoo.

The team investigates a body found in a car crash, the remains of which belong to a founder of a men's rights organization who may have been the victim of domestic abuse. As Brennan learns more about the tenets of the victim's organization, which claims middle-aged white men are oppressed and feminists are man-haters, Brennan uncharacteristically loses her cool during an interrogation and assaults the organization's co-founder. Meanwhile, Angela and the team struggle to deal with Hodgins post-wheelchair bitterness and Booth is convinced Brennan is a jinx for the Philadelphia Flyers.

After discovering the body of a man involved with creating artificial intelligence bots, the team must figure out whether the victim's own A.I. bot was programmed to kill him. In the meantime, Bones plans a special surprise for everyone for her 40th birthday.

When a young man dies in a horrendous hay baler accident, Booth, Brennan and Aubrey slap on trashy disguises and go undercover at a rowdy demolition derby competition to investigate the case. Meanwhile, Dr. Gordon Wyatt returns and assists Hodgins and Cam when the ongoing Gormogon case hits a dead end.