After it's determined that a wealthy woman did not commit suicide but was murdered, the detectives question both her first and second husbands and her teenage daughter.

Briscoe and his new partner, Det. Reynaldo Curtis, investigate the murder of a young girl who disappeared between school and her music lesson, with a blurry film from an ATM machine as their clue.

The murder of a deadbeat father whose son is dying of leukemia presents McCoy and Ross with a sympathetic suspect and a moral dilemma.

After a 12-year-old quadriplegic dies at home in his bed, paramedics claim that he was suffocated and the suspects include the boy's parents and sister.

After a child in a day-care center dies of a virus, Briscoe and Curtis try to find the source of the infection, leading to a case involving an extramarital affair, embezzlement and a drug manufacturer.

The murder of an audio installation salesman leads the detectives to a case with connections to the mafia.

After sanitation workers find a teenage boy's body, the investigation leads to a school bully who displays an avid interest in martial-arts weapons, and whose father bought the murder weapon.

After a disabled boy dies of smoke inhalation during a fire, his parents and a building tenant with a history of ""accidental"" fires become suspects.

When a celebrity is implicated in a nightclub murder, McCoy and Southerlyn battle the flaks who attempt to insulate their client from any involvement or interrogation.

The investigation of a woman's strangulation leads to a case involving the selling of drugs and a gangster's son.

An American Muslim becomes the prime suspect in a double murder after an academic challenges his religious beliefs.

The investigation into the murder of a former bookie turned mob informant reveals a disturbing new wrinkle in organized crime involving legitimate businessmen moonlighting as contract hitmen in a battle for mob leadership, and ends with a Federal ploy to nullify the plea bargain in the case, leaving McCoy seething and two more people dead.

Fontana and his temporary partner, Det. Nick Falco, must tread lightly when they discover links between a powerful police commissioner and the murders of an infamous porn actress and a maverick publisher.