On a small freighter, Kimble is traveling to Alaska when an FBI agent, named Paul Vale, arrives and begins questioning him and all the passengers in a search for a Korean War criminal and traitor. Vale becomes most suspicious of Kimble, as well as passenger George Banning and his wife Adrienne whom are embezzlers fleeing the States. When Vale is found murdered the next day, Captain Carraway interogates all the suspects and when the captain discovers that Kimble's references are fake, Kimble becomes the chief suspect.

While working at a construction site in Utah, Kimble convinces his supervisor, Buck Harmon, to hire Jamie, a mentally disabled but physically strong young man, to help out. Because Jamie is an easy target for the taunts of the other work crew members, Kimble becomes Jamie's protector. When Jamie is accused of sexually assaulting Buck's wife, he becomes frightened and runs away. The crew foreman, Dan Pike, convinces Buck to organize a posse to hunt down Jamie and kill him.

Kimble returns to his home town in Illinois after learning that his father, John Kimble, has suffered a heart attack and has donated his medical library to the University of Wisconsin and in the process of selling the family house. While Kimble hides out at the home of his sister Donna and her sympathetic husband Leonard, Kimble blames himself for his father's condition, but is more troubled by his younger brother Ray, whom belives Kimble is guilty and thinks he's to blame for ruining his life since people see Ray as ""the brother of a killer."" Meanwhile, Gerard arrives in town to search for Kimble and focuses on Donna and Leonard whom try to shake off the relentless detective long enough for Kimble to get out of town before Gerard finds him.

Beliving that the one-armed man is in Chicago, Kimble contacts Mike Decker, a newspaper columnist who defended Kimble during his trial. Kimble and Decker organize a city-wide search for the one-armed man. But things get complicated with the arrival of Decker's alcholic wife, Paula, whom gets nervous of Kimble's presence and falls off the wagon. Meanwhile, Gerard learns about Decker's search for a one-armed man and decides to use the writer to set a trap for Kimble.

Herbie Grant, a second rate hoodlum, is shot in the leg while trying to rob a liquor store that Kimble works at. Herbie later takes Kimble hostage where Herbie claims that although he tried to rob the store, he is innocent of two other liquor store robberies in the other towns. Kimble agrees to help clear Herbie in which the hood lets the fugitive go. Kimble is summoned to the local police station to give his statement on the robbery where he is recognized by Herbie's sister, Lorna, whom works at the local post office. She threatens to turn Kimble in unless he turns over her brother whom she belives to be guilty of those other robberies. But at a local motel where Herbie is staying at, he is recognized by a maid who calls the police and they arrest him. Thinking that Kimble doublecrossed him, Herbie reports Kimble to the police.

While working as a health club masseuse, Kimble is recognized by Sheriff Bray, a local lawman with policial aspirations. But Kimble manages to escape with the help of co-worker Steve Edson. After confiding with Steve his secret, Kimble learns that Steve is a fugitive of conscience: five months earlier, Steve was tried and acquitted for the murder of his girlfriend Linda's abusive brother, a murder that Steve actually committed and he apparently cannot live with the guilt over having gotten away with it. Kimble reluctantly lets Steve travel with him. But Steve begins leaving behind clues that soon puts Sheriff Bray back on their trail, including contacting Linda for help and letting her vengeful other brother, Joey, track them down.

While working as a warehouse worker, Kimble is recognized by the Greek-born owner, Gus Priamos. Gus tells Kimble that he is dying from cancer and has only six months to live and hopes to aid the Fugitive with a scheme to make it look that Kimble has fled the country to Greece. But when Gus' jealous girlfriend Sophie learns Kimble's idenity through a magazine article, she contacts Gerard whom gets a heads-up on Kimble and Gus' plan.

While working as a research technician for the wealthy Allan Pruitt, Kimble gets involved in the business of Allan's teenage daughter, Janice, who returns home after spending a year in a mental hospital recovering from a nervous breakdown after witnessing a young boy under her care get killed by two vicious stray dogs. But Allan's new wife, Dorina, does not take a liking to Janice and plots to drive her insane by hiring a neighbor to make his pet dogs bark in the nearby woods and convince Janice that the dogs are alive (they were captured and put to sleep by the local dog catcher.) But when Kimble claims that he has heard the dogs barking, Dorina asks the local sheriff to investigate Kimble to find any dirt on him.

A discarded photograph, with Kimble in the background, leads Gerard to Chicago where he assembles a team of detectives where they trap Kimble within an eight-block radius of the city. With Kimble wondering from place to place, and being recognized by whomever he comes into contact with, he flees from both policemen and local citizens, finding refuge in a small house which is the home of two middle-aged men, named Jake Devlin and Sam Reed, whom have long argued over his innocence.

Kimball escapes from his workplace at a hatchery just as Gerard and the local sheriff come to arrest him. As Kimball drives off in the sheriff's car, he discovers that Gerard's son is hiding in the backseat.

Kimble finds refuge from the police in a rural farm house, where he meets Mattie Braydon, a sculptress who suffers from hysterical blindness whom lives with her older sister and their uncle. Mattie protects Kimble and while hiring him as a farmhand, she also begins using him as a model for her clay sculptures see keeps in the barn. But Kimble soon finds out that the sweet and innocent Mattie is in fact a possessive and manipulative sociopath who wants Kimble for herself and will do anything, including committing murder, to ensure her dark secrets of her past never get revealed.

On the verge of closing in on the shadowy one-armed man, Kimble is renderd amnesiac after a freak gas explosion at a roadside diner. While the Fugitive fights to regain his memory, a struggle ensues at the local hospital between Margaret Ruskin, a sympathic social worker whom regonizes Kimble and belives him to be innocent, while a local physician, named Dr. Towne, belives Kimble to be guilty. Meanwhile, the one-armed man slips away, but not before he makes an anonymous phone call to the police and Gerard about Kimble's whereabouts.

While working as a steward at a remote desert resort, Kimble is unaware that the area is a top-secret government test site for chemical weapons. Kimble tries to leave, but gets mistaken for a spy by Major Beck, the head of the project. When several staff members, including the staff physician, suffer from a resulting chemical explosion, Kimble is pressed into service to care for the wounded, unaware that Beck still plans to turn him into the army general leading the project.

After a diver dies in an underwater mishap, Kimball comes to the defense of the diver's girlfriend-whom the locals believe is a jinx. Kimball knows that the death may have been due to negligence- knowledge that puts him in jeopardy.