While hoping freight trains, Kimble meets a young woman named Carol Hollister with her baby whom she is traveling to meet her husband. But Kimble doesn't know that Carol is a mentally disturbed young woman whose newborn baby died a year earlier and she has abducted another baby. Soon, Carol becomes so far gone that she mistakes Kimble as her late husband. Kimble must find a way to get the baby away from Carol and return it to it's rightfull parents while avoiding the police looking for her.

While working as a hotel steward in Wyoming, Kimble is forced to run after learning that another hotel employee has stolen hotel funds, and Kimble becomes the suspect. Kimble escapes on a tour bus containing a bickering couple called the Langners, a visiting spinster named Louanne, a local guy named Sandy Baird, and the bus driver. But Kimble becomes trapped when the bus breaks down on a back road, and all the passengers discover his secret when his identity is revealed over the radio. Held at gunpoint, Kimble must find a way to escape by emotionally getting between his various captors before the bus driver returns with the police.

Running from the police, Kimble hides out at a farm owned by a local country doctor, named Josephus Adams, whom treats his patients with little more than a dose of honey and a reassuring word. After one elderly woman under Adams care dies from a protracted bronchial infection, an angry Kimble intervenes and tries to help the patients. But in the meantime, Adams' wife, Marianne, stumbles upon Kimble's identity and tries to use that to her own advantage. When Dr. Adams teenage niece, Sharon, falls into a coma after having an alergic reaction to bee stings, Kimble risks his freedom to take her away from Adams to a hospital for treatment.

In rural Wyoming, Kimble seeks refuge from the local constable at a small hotel run by Lois Carter, a young widow whom hires him as a handyman. Kimble soon befriends Lois' son Kenny, a particularly sensitive young boy whom protects Kimble from the police when they arrive looking for him.