Richard Kimble rides into Tucson, Arizona under the name James Lincoln. He checks into a hotel and finds a job as a bartender at the Branding Iron. He meets Monica Welles (Vera Miles), the piano player who escaped from her stalking jealous husband (Ed Welles) played by Brian Keith.

Kimble finds work as a cut man for boxer Joe Smith. Joe confides in Kimble that he wanted to be a doctor, but he chose boxing because he felt that being a black man would be an obstacle in the world of medicine. When Kimble discovers that Joe is suffering from memory loss, both he and Joe's wife, Laura, fear that Joe might have brain damage from his boxing. Meanwhile, a police detective, named Henry Stone, goes undercover as a sports writer to investigate Joe's manager, Lou, for possible mob ties. But when a distgrutled boxing worker tips off Stone that someone might be wanting Joe to throw his next fight, the detective investigates Kimble.