When Bernie and Tony secretly watch a football game on which they've placed a large bet in order to hide their gambling from Bernie's mother, she finds out and wonders what kind of influence Tony is having on her son. Meanwhile, Megan and Mickey are wrapped up in a Thanksgiving dilemma when they accidentally break the dining room table and try to cover it up.

Tony's policy of not talking to his new neighbor backfires when he and Dana discover they have not been invited to a neighborhood party. Meanwhile, Mickey is dating a girl, Rebecca, and he realizes that they only do what she wants to do.

When Dana goes out of town to supervise a monkey transfer from the Chicago Zoo, Tony invites Bernie to recuperate from his knee surgery and enjoy a weekend of relaxation at their house. The friends enjoy a few days of watching movies and eating nachos in bed, while Bernie helps Tony with his parenting duties. However, the ""honeymoon"" quickly comes to an end when Bernie's girlfriend shows up and Megan ends up sneaking out of the house.

Dana tries to ward off her feelings of middle-age by getting a tattoo. When Tony expresses his disapproval, Dana vows to remove the tattoo if Tony can lose ten pounds. Meanwhile, Megan discovers that Mickey's new girlfriend is cheating on him with another boy, but Mickey doesn't believe her.

The Kleinmans are thrilled when their neighbors, Andrew and Jane, agree to give Dana a large donation for the construction of a petting zoo. However, Tony ends up in hot water when he interferes and delays them from getting the check. Now, Tony must take extreme measures to get them to pay up.

When Mickey starts hanging out with Bernie's niece, Erika, Tony invites them to the studio to show them off to his colleagues and prove how liberal he is. When Bernie accuses Tony of grandstanding, Tony asks Bernie why he doesn't invite him to hang out with his friends. To prove his point, Bernie does extend the invitation with surprising results.

When Tony and Bernie go to Las Vegas to promote their show, Tony anticipates a fun ""guys' weekend"" with Bernie, until Dana suggests she and the kids come along to spend their 20th wedding anniversary together. Dana gets angry when she realizes Tony would rather be elsewhere and urges him to go with Bernie to a club, as she is too upset to spend any more time with him. Instead, she decides to attend a Penn and Teller show, at the personal request of Teller, whom she met earlier in the day. When Tony realizes he'd rather be with his family, he plans a surprise for Dana and the kids that's sure to have them ""all shook up.""