Martin, while fooling around with a much younger college girl (an Eddie Charles hook-up), ends up in the hospital. His doctor instructs him to change his lifestyle around to prevent another (possibly worse) incident. Top of the list? Cut out caffeine. Of course, he receives a lot of ridicule as he goes about this.

Martin is a member of the audience of the ""Eddie Charles Show."" Today's topic is about the current weak nature of the male gender. Martin, inspired by the guest author of the show, decides to go away to a male-bonding workshop. At the retreat, Martin learns that he is an elephant. After a somewhat disappointing time, Martin returns home.

Back in New York, Martin runs into the ""perfect woman"" (Mary) at a supermarket, and they begin a relationship. Mary cooks, cleans and takes care of Martin. Mary is very ready to help and loves to allow Martin to make all the decisions. Mary also expects and encourages Martin to have guests over to watch sporting events on television. Oddly enough, Martin is starting to find Mary grating.

Martin decides to take his first vacation in a long time, and visits a travel agent. Many expensive options are presented, and Martin settles on Bermuda. Martin is eager and happy to begin his vacation, until his boss visits him. The boss, Sid, wants to know if Martin has heard about the current tragic news circulating throughout the city. The current news story is about the gruesome murder of a family that included the butchering of their dogs. Before Martin can go on his vacation, he has to get the widow signed as an author with Whitestone. The person that would normally do this is out sick. Martin is very reluctant, but cannot say no. Martin finds himself to be rather good at this type of activity, but does not like this fact. The widow, Lyia, is not sure if she wants to drag the sordid mess out before her fellow citizens. They've hounded her enough. On the other hand, she might be tempted to tell her story. At the same time, the police have yet to find the killer.

Martin has clothes in the dryer, and more in his arms, as he returns to the laundry room. Martin returns to find a woman that Martin has not seen before reading a book and doing her own laundry. An instant attraction is sparked in both. While chatting with the woman, Nina, Martin finds that his clothes that were in the dryer have been removed and are damp. Martin is very annoyed and expresses his rage at the idiot who removed his clothes and put their many pairs of pants into the dryer. Nina notes that Martin should have been there when the dryer was done, and she wouldn't have had to remove his clothes. Just then the dryer stops. Martin opens the door, Nina protests that the clothes are still wet, and instead of continuing the argument, Martin and Nina kiss and explore each other. The activity continues in Martin's apartment, and involves several days. Office mates, notably Toby, are annoyed at the missing Martin. While extremely happy, Martin and Nina's relationship suddenly

Despite the continuing distraction of a prior boyfriend, and the deep involvement in the protest movement, Nina and Martin are still together. Nina suggests to Martin that they take the next step in their relationship – an AIDS test.

Martin's friends and family offer support after Nina's arrest, but he prefers to be alone. While resting in his apartment, Martin receives a call from Irma, a suicidal woman trying to reach 555-HELP. Martin's phone number, it turns out, is 555-HELL. As Irma wants to exit this world at midnight, and as it is only three minutes to midnight, Irma doesn't want to contact the correct phone number. Martin tries to keep her on the line, and keep her from killing herself.

Cousin Phil visits, and informs Martin that he has split up with his wife (shrew). While in Martin's office, Phil sees Toby for the first time, and is smitten. Phil begs, and Martin helps Phil pursue Toby.

An old female friend of Martin's, Bonnie, returns to New York City from Cleveland to pursue a stand-up career. Bonnie's first performance as a stand-up bombs. Martin tries to encourage her by suggesting that she should use her past relationships in her act (which has more humor in it than her current act). Martin and Bonnie start to fall for each other and end up sleeping together.

The whole gang shows up for Bonnie's second performance as a stand-up comic. Bonnie, following Martin's advice, discusses her relationships in her act. Unfortunately for Martin, Bonnie sticks to talking about her current relationship. The gang, and the audience, except for Martin, love the new act. Afterwards, the gang offer Bonnie funny stories about Martin.

Alone together back at Martin's apartment, Martin almost starts to tell Bonnie about his reactions to her new act. A phone call interrupts. An HBO scout was in the audience and loved the act. Next Friday, Bonnie is informed, an HBO big-wig wil

Gibby convinces a reluctant Martin that the big Xmas book should be the memoirs of a gay man dying of AIDS.

Martin convinces Toby to marry Gibby so that he can get his green card, but becomes annoyed when the wedding plans disrupt her work.

Martin overreacts when he suspects that Jeremy has begun to have sex.

Everything seems to be going great in one of Martin's relationships. He and Kate couldn't be happier, and they plan on living together at Martin's apartment.

Martin's divorced father Mickey comes back to live in New York. Martin fixes him up with Toby's mom Angie on a dinner date. He takes her home, but to Toby's irritation ‘does nothing' to her. Martin visits the one- bedroom apartment Mickey is sharing with apartment owner Roger.

Martin, Eddie and Judith meet up at a secluded cabin for a reunion with old friends. Martin has ongoing mutual antipathy with Allison, an old writing rival who has since gone onto fame and success as an author. Eddie is anxious at seeing Cara - a woman he slept with once and never called again, although on first meeting she doesn't recognise him except from his TV show.

Martin and Judith take a pre-Xmas drive and get stranded in a barn, Eddie is stood up by a girlfriend and spends Xmas in a bar with Santa Claus, Toby wants to become a nun and Jeremy's special Xmas present from his girlfriend doesn't quite go according to plan.

Martin and Judith take a pre-Xmas drive and get stranded in a barn, Eddie is stood up by a girlfriend and spends Xmas in a bar with Santa Claus, Toby wants to become a nun and Jeremy's special Xmas present from his girlfriend doesn't quite go according to plan.

Martin thinks things are getting out of hand after Judith discovers "some little tricks" to improve her sex life.