James West and Artemus Gordon help evacuate the town of Tonka Flats before it is destroyed by a cannon shell. Afterwards, they are notified that a man identified as ""The Falcon"" has threatened to obliterate Denver unless the U.S. government pays him $1,000,000. ""The Falcon"" is also in cahoots with syndicate leaders from Turkey, Spain, Prussia and England. During their investigation, Gordon is threatened by a whip-wielding Spaniard named Munez who suspects Gordon knows too much about the top secret weapon. West rescues Gordon from Munez, who is then killed by an explosive meant for the two agents. While searching Munez's body, West and Gordon find an invitation from ""The Falcon"". Gordon, disguised as Munez, prepares to attend the meeting while West attempts to penetrate the stronghold where the cannon is housed.

The guys become involved with a voodoo ceremony and the walking dead as they try to track down a missing scientist.

While on the trail of a scientist who has stolen a vial of deadly germs, the agents are pulled into a night of deadly parlor games. West and Gordon must recover the vial before it bursts and releases a veritable plague while managing to live though the games of their host.

Agent Artemus Gordon and the curator of the San Francisco Museum are set upon in the Egyptian exhibit by three men wearing gas masks. When agents West and Mr. Heisel, the Egyptian government's representative, enter the room, they are also attacked. After regaining consciousness, the men discover that a priceless ruby has been stolen from the eye of the statue of Sun God, Ra. Commissioned by Miasmin, an Egyptian Princess, to recover the gem, West and Gordon trace a ransom note to a waterfront bar where Gordon poses as a sea captain. At the bar, West recognizes one of his assailants at the museum. The man identifies himself as Jason and indicates that Rosie, a beaufiful young dancer at the bar, is wearing the ruby on her toe. Unfortunately, Rosie vanishes before West can make a move.

Agent West raids a local warehouse in an attempt to apprehend a suspected opium gang member. As he struggles with the suspect, a new secret agent named Bosley Cranston rushes in and attempts to help. Unfortunately, he only makes matters worse, accidentally toppling a piano crate on the suspect and killing him. Cranston, however, is not the meek incompetent he appears and later surprises his colleagues with his karate skills and his popularity with beautiful women.

After a series of disturbing incidents involving a raven that seems to hynoptize high-ranking officials into committing dastardly deeds,Agents West and Harper decide to find out what's going on. The incidents lead the new partners to a group calling themselves The Raven,led by Thaddeus Toombs and a man called Tycho (who has an enormous head and is very smart).

The plans of The Raven seem to be successful as they have hypnotized Jim West and had him assassinate the Mexican Ambassador. Unfortunately for the group,Frank Harper had been impersonating the ambassador to test whether Jim had been conditioned. West and Harper work together to infiltrate and undermine the group and capture everyone except for the huge-headed Tycho.

West visits an eerie island to get a diamond for the National Museum.