The year is 1827. In Virginia, young Jacob Wheeler dreams of adventure. Leaving his family behind, he joins renowned mountain man Jedediah Smith on an expedition to California. Meanwhile, a young Lakota holy man, Loved by the Buffalo, receives disturbing visions about the coming of the white man and the demise of the buffalo. When his sister, Thunder Heart Woman, is saved by Jacob, the lives of the two families become forever intertwined.

When gold is discovered in the Black Hills, the Lakota's most sacred land is threatened. The government wants mining rights, but Chief Sitting Bull refuses. He later has an ominous dream that gives hope to the Lakota. This vision becomes reality when the ambitious General Custer and the 7th Calvary are outnumbered by Crazy Horse and his warriors at Little Big Horn. But the Lakota victory fuels hatred of the Indians among those who seek to destroy them and their culture.

Loved By The Buffalo believes he has found the foretold prophet when a mysterious Indian named Wokova inspires his people with the Ghost Dance and a vision of their restored land. But the ritual stirs up more fear among those who wish to contain the Indians. Sitting Bull is “accidentally” killed, further inciting the Ghost Dance rebellion, which in turn, leads to more brutality toward the Indians. As the circle closes, Loved By The Buffalo and Jacob meet again. Reunited with his family, Loved By The Buffalo resolves to pass on his Lakota traditions to the next generation so that their ways continue to live on.