After the death of John Cable, Alex Murphy is plagued by haunting memories and seeks answers. Meanwhile, a new Robocop is created and goes after Murphy for crimes he didn't commit.

David Kaydick, an insane ex-OCP employee, forces John Cable to help him obtain the Legion virus, which will threaten the human race. Meanwhile, System Support are closing in on Robocop.

Robocop and his new allies race to OCP headquarters to try to prevent Kaydick and Cable from infecting S.A.I.N.T with the Legion virus, which would mean the end of Delta City.