We are introduced to the four main characters Pu, Ngoh, Duean, and Pam and their different family backgrounds. Pu lives in Kanchanaburi and wants to move to Bangkok to live with her mother while Ngoh's family just moved to a different part of Bangkok to open a new shop. Duean and Pam live in the poorer neighborhoods within Bangkok where Duean's father works as a construction manager and is looking to buy a new house. Pam's father is a police officer and her mother has a gambling problem.

Duean visits her father at the hospital while Pu moves to Bangkok to live with her mother and her new husband. Ngoh's father is wary of his wife as she seems a bit too friendly with the customers. Duean's father's condition worsens and Pam's mother continues to gamble.

Louis becomes distant with Pu after receiving some news. Pu starts to miss him and Ngoh consoles her. Pam is back on her heroin addiction and Ngoh, Duean, Pu, and Joe are desperate for it. Pu returns to Kanchanaburi to steal money from her father and discovers he has a new wife.

The main characters reach the peak of their heroin addiction and really attempt to stop.

The story wraps up as the four girls slowly wean off drugs and struggle with drug withdrawal.