A much-needed vaccine arrives in Deadwood. There are rumblings of a treaty with the Sioux. Swearengen is reluctant to accept advice from Farnum while Trixie is away. Alma reconsiders her plans for her gold claim. Stubbs learns an important lesson from Tolliver.

Swearengen receives a double dose of irritation when a drug supply is stolen and bad news arrives from a nearby town. Rev. Smith is an unlikely customer at the Gem. Merrick hatches an idea for Deadwood's first club.

Cochran's ominous prognosis puts the camp on alert. Smallpox survivor Andy Cramed returns as a minister. Swearengen asks an unlikely pair to pull a scam on Commissioner Jarry. Martha Bullock has second thoughts about staying in Deadwood.

Tolliver looks for a representative, the Captain calls Dan out, Swearengen continues to be perplexed by Hearst's moves, and Alma and Ellsworth's relationship takes a turn.