House and his team have to act fast when a high school student is admitted with a mysterious and lethal poisoning, especially when they discover more teens have been diagnosed with the same deadly illness.

Dr. House and the team treat a homeless woman whose worsening symptoms and unknown identity prove to be a complex mystery.

The hospital's new Chairman of the Board has it out for Dr. House, questioning his importance to the hospital and threatening to eliminate House and his team.

House and his team battle to save a presidential hopeful, and House refuses to give in to Vogler's ultimatum when given the chance to save one of his team members.

House and his team tackle the case of a young man with a penchant for odd behavior, and House prepares for his date with Cameron.

House is faced with a problem he may not be able to solve and Stacy returns.