Detective Sherlock Holmes, along with his sober companion, Dr. Joan Watson, uses his uncanny ability to read people and analyze crimes to assist the NYPD on some of their more difficult cases. In the season premiere, Holmes consults on a home invasion that resulted in murder.

Sherlock uses his powers of deduction to consult on the murder of a young man who is shot upon entering his apartment. Meanwhile, Watson has dinner with her ex-boyfriend, Ty Morstan.

Sherlock is reunited with “M.” a British criminal who appears to have followed Sherlock to New York. Meanwhile, Joan has reservations about leaving Sherlock and taking on a new client.

Sherlock pursues Martin Ennis, an unpredictable criminal, before he strikes again. During the investigation, Sherlock is forced to work alongside Kathryn Drummond, the FBI profiler who literally wrote the book on Ennis. Meanwhile, Watson faces eviction from her apartment.

As Sherlock reels at the reappearance of his former lover, Irene Adler, a series of flashbacks unravel the tumultuous events that led to his downfall into addiction. Meanwhile, he and Joan once again find themselves in the crosshairs of the enigmatic Moriarty.

As Sherlock reels at the reappearance of his former lover, Irene Adler, a series of flashbacks unravel the tumultuous events that led to his downfall into addiction. Meanwhile, he and Joan once again find themselves in the crosshairs of the enigmatic Moriarty.

Sherlock is called to London to revisit an old case, where he is forced to face his older brother, Mycroft. Although the siblings suffered a drastic falling-out a few years earlier, Mycroft allows Sherlock and Joan to stay in his new home, 221B Baker Street. With Joan in the middle, the brothers are forced to confront their very complicated history.

Holmes and Watson come face to face with Moriarty when their one-time adversary is brought in as a consultant on a kidnapping case. Meanwhile, Detective Bell continues his struggle on the road to recovery.

Rising tension between Sherlock and Joan brings their partnership to a crossroads, but they endeavor to put their differences aside while they help Sherlock's brother, Mycroft, who faces accusations of treason and murder.

Sherlock returns to New York with a new apprentice and a renewed interest in working with the NYPD after being fired by London’s MI6. However, Gregson won’t let him resume consulting for the department without permission from his former partner, Joan, the NYPD’s new go-to private investigator.

As Kitty begins to unravel due to the imminent threat to her safety, Sherlock and Joan intensify their efforts to help her. Also, the origin of Sherlock and Kitty’s relationship is revealed.

Holmes and Watson take on an investigation of a personal nature when Holmes’ recovery sponsor, Alfredo, suddenly disappears. As they delve into Alfredo’s life for clues, Holmes questions whether their friend has been abducted, or worse, if he suffered a relapse into addiction.

When Holmes faces criminal charges in the aftermath of his recent violent behavior and relapse, his powerful father arrives in New York to fix his estranged son’s legal difficulties by any means necessary. Also, with Holmes and Watson’s consultancy with the NYPD in jeopardy, Holmes concentrates on the case of a missing wife believed to have been killed by her husband to try and get back in the department’s good graces.

When Holmes and Watson discover the perpetrator behind the attempt made on Morland’s life, they find a shocking connection to themselves.

Holmes and Watson’s lives are threatened by an influential, worldwide criminal network connected to the murder attempt on Morland Holmes. Also, Sherlock’s grievances with his father threaten their alliance to bring their mutual adversary to justice.

When a serial bomber becomes active again after being dormant for six years, Watson seeks help from Shinwell Johnson, a former patient whose life she saved when she was a surgeon. Also, Holmes senses Watson is unhappy and questions whether she is still fulfilled by her detective career.

Holmes’ former protégé, Kitty Winter, returns to New York after a three-year absence to warn him that a killer is eliminating everyone involved with a case they worked on together in London, and they’re the next targets. As Sherlock, Kitty, Joan and the NYPD join forces to find the perpetrator, Watson discovers Kitty has a life-changing secret.

Joan and Kitty try to prove that a string of murders, stemming from an old case Sherlock and Kitty solved in London, is connected to an international government conspiracy with the Defense Intelligence Agency at its center. Also, Sherlock and Kitty’s relationship is strained after she shares life-changing news.

Season 5 ends with Holmes and Watson pursuing an elusive criminal as a gang war erupts in New York City. While the NYPD works to contain the violence, the two investigate the murder that appears to have ignited the city-wide conflict and discover that a familiar face is pulling the strings.

Holmes and Watson face their greatest challenge to date when a murder investigation threatens to destroy their partnership.

Amidst Holmes and Watson’s battle with tech billionaire Odin Reichenbach, the investigators receive word of their old enemy and Sherlock’s former love, Jamie Moriarty.