Information about Amelia's past emerges and causes problems for her at the hospital.

A patient's condition sparks a conversation between Richard and Maggie about Alzheimer's disease; April and Jackson struggle to return to their normal lives and Arizona is faced with the reality that Callie is moving on. Meanwhile, Meredith reveals her biggest fears about Derek.

The team of doctors work on a high stakes case of a long time patient, adding additional pressure to an already tense environment. Meanwhile, Bailey wants Ben to kick out their new roommate, and Arizona is eager to get back into the dating world with a new wingman.

Meredith takes a step forward with Will but quickly regrets it; Maggie senses a disconnection with Andrew; and Amelia reevaluates her relationship with Owen. Meanwhile, Catherine comes into town and really shakes things up with April and Jackson.

A car crash at a funeral brings a bickering family into the hospital. Back from New York, Arizona ends up caught between Alex and Andrew. While Ben takes on a new parenting role, Amelia helps Meredith and Maggie through a problem.

Maggie gets a surprise visit from her mother at the hospital. Bailey has to make a difficult decision when one of the attendings refuses to work with Eliza, and Stephanie gets caught up in Owen and Amelia’s personal drama.

Bailey and April work to fix things between Richard and Catherine; Eliza continues to pursue Arizona; one of Alex's previous patients returns to Grey Sloan.

Jo finally faces her estranged, abusive husband Paul Stadler, while Grey Sloan continues to work with the FBI after a hacker has compromised the hospital’s computer system.

Alex and Jo go on a road trip to Iowa to find Alex’s mom, whom he hasn’t heard from in a very long time. Meanwhile, Meredith gives a presentation on her mini-livers project, which attracts a ton of attention; and Jackson works to rebuild the foundation after its reputation is threatened.

When Jackson throws a party to celebrate Catherine’s surgery and those who worked to save her, literally nothing goes as planned. Meanwhile, Helen pays Alex and Jo a surprise visit.

Alex tries desperately to save his patient Gus while he waits for a severely agoraphobic blood donor to arrive from London. Jo reveals to Meredith why she’s been so down, while Catherine and Bailey hold a meeting to get down to the bottom of an insurance issue. Meanwhile, Maggie and Jackson go camping.

A patient at the hospital is brain dead after falling into a construction site, and her two sisters must decide whether or not to keep her alive.

Richard preps to present his PATH pen at the LA Surgical Innovation Conference but becomes distracted by his issues with Catherine. Maggie and Teddy run into people from their past at the same conference, while Hayes relives moments from when he met his late wife.

The doctors of Grey Sloan Memorial must contend with the COVID-19 pandemic; an unintentionally started fire has first responders from Station 19 bringing patients into the hospital for treatment.

Bailey finds herself in the middle of an argument with patients' families as they await news about their children who were injured in a fire; Winston surprises Maggie; Amelia and Link try to have some fun as new parents.

Levi gets accepted into the vaccine trial. Meanwhile, Amelia and Owen treat a car crash patient, and Hayes and Jo are met with Luna’s legal guardian.

It’s wedding day for Maggie and Winston. Meanwhile, Meredith takes on a new role at the hospital, and Jo makes a life-changing decision.