After a burn victim unexpectedly dies in the midst of a chaotic ER, the Chief and board member Jennings interrogate the residents to find the culprit, as all the Mercy West and Seattle Grace resident defends their actions in an effort to save their jobs.

Seattle Grace Hospital is hit with a crisis like no other in its' history.

Issues surface when Derek's estranged sister, Amelia (Caterina Scorsone), visits unexpectedly; Meredith and Derek continue to try to ease Cristina back into surgery.

Owen puts the residents through a rigorous trauma certification drill; Cristina is left alone to monitor an ill lung transplant patient.

As the hospital spirals closer to financial ruin, Owen must make some tough decisions, which includes foregoing an expensive surgery that could save the life of a child. Meanwhile, Alex and Jo work together to save the life of an infant, and April asks Jackson for dating advice.