As Callie and Arizona's wedding approaches, the couple quickly realize that the day they've been looking forward to is not turning out the way they'd envisioned. Meanwhile Alex continues to make the other residents jealous as he appears to be the top contender for Chief Resident, Meredith and Derek make a decision that will change their lives forever, and Dr. Perkins presents Teddy with a very tempting proposition.

The Seattle Grace doctors are on edge when a new medical professional enters the hospital; Arizona struggles with the emotional and physical pain of a phantom limb; and while battling pregnancy hormones, an overly-emotional Meredith is confronted with her worst fear.