The residents try their hardest to impress surgical great Catherine Avery-who also happens to be Jackson's mother-when she arrives at Seattle Grace to perform a groundbreaking transplant surgery; Arizona and Alex find their hands tied with a confidentiality issue when a familiar patient comes into the ER; meanwhile, a love-struck Teddy throws a dinner party for the couples, and Bailey makes a decision regarding her love life

Derek encourages a hesitant Meredith to work with him again in neurology; Jackson's mother, Catherine Avery, returns to Seattle Grace with a urology fellow and develops an interest in Richard; and Cristina becomes increasingly suspicious of Owen's every move. Meanwhile, Alex tries to deny the fact that Morgan may be falling for him.

After eight years of practice, the residents head to San Francisco for their oral boards; sparks fly between Catherine and Richard when they bump into each other at the hotel; Bailey intervenes after Owen and Teddy get into a heated argument about their young car crash patient; and Mark tries to recruit Lexie for one of his cases. Meanwhile, Alex feels guilty for being away from the hospital when Tommy's health begins to fail.

The residents agonize over their oral boards, reliving every answer they gave during their exams; Arizona's close childhood friend comes to Seattle Grace for medical help; the doctors work on a patient who is missing one third of his skull; and Julia asks Mark to start a family with her. Meanwhile Catherine tells Richard that one of his residents has failed.

Aware that Derek might never operate again, Meredith stops talking about the surgeries she's performing. Meanwhile, Richard calls on Dr. Catherine Avery to help him perform a complicated procedure, as things continue to heat up between Jackson and April; and Arizona's struggle to accept her fate forces Callie and Alex to face their guilt.

Meredith, Derek, Cristina and Arizona receive big news regarding the plane crash lawsuit, Richard avoids Catherine's romantic advances and Jackson takes on one of Mark Sloan's old patients. Meanwhile, Derek begins recovery on his hand.

As word of Seattle Grace's financial trouble spreads, Catherine encourages Jackson to move to Boston, and the interns fear they might lose their jobs. Meanwhile, the doctors meet with a potential investor in a last-ditch effort to save the hospital, and Alex impresses Jo while caring for a patient.

The discord and chaos created by the hospital's new management team causes one physician to question his future at Seattle Grace. Meanwhile, the doctors and the interns must juggle several transplant surgeries at once, each coming with its own set of obstacles.

Callie makes a decision about her relationship; the doctors receive devastating news.

Meredith struggles to balance her roles as a surgeon and a mother when she returns to work; Stephanie tries to impress Jackson's mother; Jo becomes overly involved with a patient.

It's Richard's birthday and Bailey invites him to scrub in on the case of a lifetime. Meredith hires a research assistant to help with her portal vein project. A scorned Callie gives Derek quite the shock. Meanwhile, Shane helps screen candidates for Cristina's clinical trial and meets a young expectant mother who needs his help.

Cristina enlists Meredith to help her prepare an acceptance speech for her possible Harper Avery win and while Owen offers to attend the ceremony with her, she insists on going alone. Meanwhile, Derek feels overwhelmed between his responsibilities at home and at the hospital. April and Jackson come to a disagreement on children and religion, and Callie and Arizona try to reconnect in their marriage.

Jackson is given the daunting task of delivering disappointing news to the doctors. Meanwhile, Derek's sister Amelia drops by for a surprise visit, Richard surprises Catherine in Boston and when Bailey gets frustrated by the slow pace of her research, she makes a risky decision.

The doctors of Grey Sloan Memorial Hospital bid an emotional farewell to the beloved Cristina Yang. A possible act of terrorism rocks Seattle and causes chaos at the hospital. Meanwhile, Meredith makes a life changing decision and one doctor receives shocking news.

After several discussions with Dr. Herman, April and Jackson must face their situation head on and make a difficult decision regarding their unborn child. Catherine arrives in Seattle and bumps into Richard at the hospital. Meanwhile, Meredith tries to find someone to take care of the kids so she can visit Derek for the weekend, and Amelia shows Stephanie some tough love when they work together on a case

Maggie gets upset when Meredith dodges her questions about DC; Bailey and Ben become concerned about Ben’s brother after he is admitted to the hospital, and Dr. Herman starts to warm up to Arizona. Meanwhile, Richard feels manipulated by Catherine.

Upon realizing that Owen and Amelia have been seeing each other behind her back, Meredith comes down hard on her sister-in-law causing Amelia to rethink things. Meanwhile, Catherine springs into action when a man is brought into the hospital after his wife seeks revenge on his cheating ways.

Meredith and the staff feel the impact of losing one of their own; Jackson struggles with April's decision; Bailey and Ben argue about their future. Months after Derek's funeral, Amelia struggles with her emotions; April plans to return; and Derek's part in Meredith's life continues to grow.

The doctors of Grey Sloan Memorial Hospital are forced to put their emotions aside when a catastrophic event occurs.

As the doctors continue to tackle an unfathomable crisis, they are reminded of what is important and are brought closer together.

The doctors from Grey Sloan Memorial Hospital spring into action to save the lives of two girls with a powerful story. Meanwhile, Meredith tries to cope with the fact that Amelia is now living with her and Jackson prepares for April's return back to Seattle.

The evolution of April and Jackson’s relationship is revealed through a series of flashbacks dating back to when they first met. Simultaneously, we follow the years-long progress of one of Jackson’s patients.

Meredith takes a step forward with Will but quickly regrets it; Maggie senses a disconnection with Andrew; and Amelia reevaluates her relationship with Owen. Meanwhile, Catherine comes into town and really shakes things up with April and Jackson.

Meredith goes on an ambulance ride with Owen and Nathan to pick up a heart for a transplant patient. Musician & MS patient Kyle Diaz is admitted to Grey Sloan Memorial with a tremor in his hand, and the residents apply for the Preminger Grant. Meanwhile, Catherine continues to insert herself into Jackson and April’s business against Richard’s wishes.

Miranda continues to deal with the aftermath of Ben's reckless decision and forms an advisory committee to recommend proper disciplinary action against him. Meanwhile, April and Jackson try to put their differences aside for the sake of their baby, and Arizona makes a decision that could affect her relationship with Callie forever.

Owen and Amelia take their relationship to the next level; Alex gains some clarity on his future with Jo; and Callie and Arizona continue to struggle with the current custody arrangement.

When one of Grey Sloan’s own lands in the hospital, Bailey tries to figure out what happened while the rest of the doctors jump in to help. Meredith juggles huge secrets that affect her relationships with Alex and Maggie. While Richard helps Jo with a big decision, April and Catherine clash over the new baby.

A familiar face returns to Grey Sloan, throwing many of the doctors for a loop. With Catherine putting on the pressure, Bailey has to make a decision about Alex while a tough ER case makes Amelia’s bad day even worse.

The arrival of a new consultant puts all of the doctors on edge, especially once she starts stepping on toes in the OR. Amelia and Owen bring their personal problems into the hospital, while April explores some uncharted territory.

Maggie gets a surprise visit from her mother at the hospital. Bailey has to make a difficult decision when one of the attendings refuses to work with Eliza, and Stephanie gets caught up in Owen and Amelia’s personal drama.

The residents are excited for Eliza’s next phase of teaching, but they spend the day caught between the warring attendings. Meanwhile, April has a challenging first day in her new role at the hospital.

Richard, Jackson, April and Catherine tackle a grueling trauma case intensified by hospital politics. Amelia finally faces her feelings about Owen, and Meredith gets caught between Nathan and Alex over a patient.

Jackson and April travel to Montana in order to perform a complicated surgery on a young patient, but Jackson’s mind is elsewhere, and April is forced to step up and get him back on track.

Bailey and April work to fix things between Richard and Catherine; Eliza continues to pursue Arizona; one of Alex's previous patients returns to Grey Sloan.

The doctors’ lives are at risk after a dangerous patient escapes the hospital room. Alex must make a hard choice in his relationship with Jo while Meredith has some big news for Nathan that brings things to a turning point.

Harper Avery arrives at Grey Sloan, putting Bailey on edge. A familiar face from Meredith’s past returns as a patient, and Amelia tries to manage a secret.

Amelia confronts a difficult situation, while Meredith deals with the fallout from her conversation with Nathan. Maggie finds herself at an awkward family dinner, Jackson receives big news, and Richard and Bailey search for the stars of tomorrow.

After a roller coaster car falls off the track at the county fair, the doctors at Grey Sloan tend to patients who spark memories about ghosts from their past. The series 300th episode!

The stress of managing the hospital and coming to terms with Ben’s decision to become a Seattle firefighter pushes Bailey to her limits.

April is in charge of the new Grey Sloan Surgical Innovation Contest, and the doctors are eager to start their projects. Meanwhile, Catherine’s old friend has a shocking idea for Catherine and Jackson; and Meredith treats a returning patient who inspires her project.

Maggie and Jackson are enjoying spending time together, but he must turn his concentration toward the groundbreaking vaginoplasty surgery he has scheduled with Catherine and Richard. Meanwhile, Meredith and Jo hit a roadblock with their contest submission, so Jo helps Bailey with an incoming trauma patient who used to be an astronaut

An agent from ICE shows up at Grey Sloan in search of an employee who may be working in the U.S. under DACA. Alex’s patient Kimmie wants to leave the hospital to enjoy her final days, but Alex feels differently. Meanwhile, Arizona treats Matthew Taylor’s baby and April wants to do whatever she can to help.

During presentations on Grey Sloan Surgical Innovation Prototypes Day, Arizona shares cookies from an appreciative patient that, unbeknownst to her, contain a special ingredient. Meanwhile, Catherine reveals shocking details to Jackson about his grandfather's past; and Jo steps in mid-operation on a major surgery.

The hospital brings in crisis management to help them sort out allegations against Harper Avery. Nurse Olivia shows up at Grey Sloan with her son, throwing Alex and Jo for a loop Arizona decides to spend more time with Sofia who is having a hard time at school.