A man is killed after winning a fortune and then dumping his girlfriend. So, Grissom, Nick, and newcomer to the CSI team, Sara Sidel, investigate this one. Holly Gribbs is in the hospital and Warrick is up for suspension for leaving her at the crime scene by herself. Holly later dies in the hospital, but Grissom doesn't suspend Warrick.

The entire team investigate the abduction of the infant child of a well to do family. Suspicion immediately falls on the child's parents.

The team is investigating the ongoing murders by a signature killer. The killer has some knowledge of forensics and has left little evidence behind. With the investigation somewhat stalled, the sheriff invites the FBI to join the case. This makes Grissom angry and it only gets worse when Sara offers to bait the killer.

The entire CSI team investigates a disappearance at a local university. A young woman vanished, seemingly off the face of the earth.

Grissom and his team investigate a murder suspect who is caught red-handed -- burying the victims -- while Catherine and Warrick take on the case of a woman found dead in a hotel spa.

Grissom and his crew are called in to investigate the death of a young woman found in the hotel room of popular actor Tom Haviland. Haviland admits that he slept with her, but denies killing her. Grissom believes otherwise, however, after finding blood evidence on the celebrity. Then things get personal when Haviland's lawyer hires Grissom's former mentor, Philip Gerard, to find mistakes in the forensic part of the case. And, unfortunately for Grissom, Gerard finds plenty of errors to exploit.

Grissom and Catherine investigate the murder of a despised comic who died onstage, apparently after drinking from a tainted bottle of water. The case grows more puzzling when a 15-year-old boy dies in a convenience store after drinking the same brand of water. Brass reopens a woman's accidental-death case after spotting the deceased's husband in a flashy new car with a trophy date on his arm.

Two couples meet in a bar and one of the couples is murdered. When a second couple is murdered in a similar fashion the team suspects a pair of serial killers are on the loose. The case is complicated by leaks to the press and a judge reluctant to issue a warrant. Catherine gets some troubling news about her father's murder trial.

When the lead suspects in Grissom's serial killer case are murdered, Grissom suspects an inside job. Grissom and Brass are at odds when Grissom suggests it was a cop. Catherine and Sara investigate what happened to a college football fan when his bloated body is found in a bathtub.

The team is introduced to the ""Furry"" side of Vegas when a man is found dead on the side of the road, dressed in a racoon suit. Elsewhere in Vegas, a gunshot victim is found in a deep-freezer, frozen solid.

A suspect's infatuation with Catherine results in her taking over a high profile case. The case is a missing woman who aspired to be a showgirl. Sara and Nick are angered since it takes the career making case away from them.

A child is abducted. As the Amber Alert goes out, the entire team investigates in a race against time. Lindsay Willows is found hitchiking to the alarm of Catherine.

The CSIs must investigate when a party girl is injured and killed in a traffic accident.

A wealthy defense attorney is killed at her son’s wedding but Nick’s car, containing all the collected evidence is stolen and the case is compromised. After discovering new evidence, the team suspects that someone from the wedding party may be responsible for the murder.

Grissom attempts to get a confession from a neighborhood pedophile by having him help in locating two missing boys. The sex offender is the main suspect. The investigation is more complex than the team ever thought it would be.

CSI investigates the death of a little girl whose identity remains unknown.

A hypnotist bank robber becomes the prime suspect in a murder investigation.

The team has a hard time investigating a shooting in Koreatown when none of the witnesses will talk about the crime.

The detectives search for the murderer of FBI agent Billy Ray Jackson, only Billy Ray isn't really an FBI agent, and neither are his impressively capable partners, Miles Baker and Emma Solomon.

A cache of missing chips from a closed down casino turn up in Vegas and a string of murders follow, leading Langston to use deadly force for the first time in his career as a CSI.

A rising young star is killed in a wreck and her determined stalker claims credit, but the team finds out there's more to this tragedy than meets the eye.

When the CSI team investigates the brutal murder of a family, they trace the killer to the house next door, which might belong to the "Dr. Jekyll" serial killer.