The whole team must investigate a crime where a husband and his porn star wife were murdered execution style. Things get personal for Catherine when Grissom talks to her about her evaluation. Brass believes that Sara may have some type of problem.

A serial killer strikes again, and the CSI team tries new technology using evidence from a prior killing. They find a fingerprint belonging to Jesse Acheson, who becomes the prime suspect. A boy confesses to the killing of his brother, but evidence suggests that he may not have committed the crime.

Catherine and Brass investigate the case in which a man is found dead in a dumpster. It soon turns out the man had a serious food problem. The trail of his death soon leads to a hotdog-eating contest.Meanwhile, Nick and Sara investigate a not-so-amicable divorce with a bizarre twist. So bizarre it eventually lead to murder when both are found dead and it looks like the dog killed one of them.

The investigation into a body found in a chimney leads the CSIs to re-open an investigation of an unsolved homicide of a female teenager named Caroline Fitzgibbons.