Grissom, Sara, and Nick investigate a wildfire that killed one man and badly burned a woman. Catherine, Nick, and Warrick get the case of a family of three murdered in their home.

Catherine and Brass investigate the case in which a man is found dead in a dumpster. It soon turns out the man had a serious food problem. The trail of his death soon leads to a hotdog-eating contest.Meanwhile, Nick and Sara investigate a not-so-amicable divorce with a bizarre twist. So bizarre it eventually lead to murder when both are found dead and it looks like the dog killed one of them.

When a student is arrested and tried for the murder of a popular high-school girl, the suspect's 12-year-old sister confesses to the crime. This results in the judge giving the prosecution 72 hours to re-examine the evidence before the jury delivers its verdict.

Coming straight from the perspectives of five people: Donna, Rebecca, Jack, Lou and Ray. All with one thing in common. They’re all dead. Brass and Catherine get to handle the case of Donna, who’s a cop from San Francisco, moonlighting as a bodyguard. Warrick and Greg work the case of Rebecca, who’s a former supermodel who died while hiking with her new husband Gavin. Nick and Sofia handle the case of Jack, a returning veteran from Iraq, who was killed in front of his wife and baby daughter who he just met for the first time. Grissom and Sara take the case of Lou and Ray whose bodies were found in Lou’s garage.

Catherine testifies in a murder trial in which a man is accused of murdering his own mother three years ago, but the suspect is found not guilty. Catherine, however, believes he did commit the crime and that he may also have killed two other people, so she sets out to find the other victims. Grissom prepares to leave on a four-week sabbatical.

The terrified eyes and cryptic words of a murder victim haunt Sara while she processes the house where several showgirls were killed.

Sara questions her future as a CSI when a past case comes back to haunt her, the 12 year old Hannah, who has to back up her brother one more time with all new tricks up her sleeves.

The murder of a mother and her child seems to be connected to a murder case from 12 years earlier.

After a beloved college football coach is found dead and his house drenched and spattered with his blood, the CSI team hunts for the killer who didn't find Coach Jimmy lovable at all.