Lois’ kleptomania lands her in jail, leaving the Griffin household in a worse state of disarray than usual. Peter and the family break her out and end up fugitives in Asian Town.

Peter's mom gets a divorce. Peter feels abandoned until he sees a father figure in his mom's new boyfriend, Tom Tucker. Meanwhile, Brian gets his own NPR style show on the radio.

Quagmire takes Peter to work but Peter messes things up, causing Quagmire to lose his job as a pilot. After not being able find another job, Peter and Cleveland make plans to help him get his old job back. When the plan fails, Quagmire receives advice from his idol, Hugh Hefner.

James Woods returns to seek revenge against Peter. James Woods finds Peter's wallet, which he lost at Barry Manilow concert, and procedes to steal Peter's identity, and his family. Peter decides to ruin James' career and image.

When Brian begins dating an older woman, the family begins to make fun of him. After Brian's new fling breaks her hip, he gets the pleasure of becoming her errand boy.

Quagmire can accept his dad's lifestyle choices, but not when they involve Brian.

Meg is enlisted to check in on Susie and Joe while Bonnie is away but she soon becomes a little too involved. Meanwhile, Stewie accidentally creates an evil twin.

When Meg turns 18, Quagmire tries to make his move on her, but Peter tries to stop him.

One mini-episode introduces a British version of the Griffins. A comedian takes over Quahog in another. And a third views the world from Stewie's POV.

As the Griffin family is preparing for Christmas, Peter tells his own version of the Nativity story.

When Peter takes Stewie to the park for some quality father-son time, he mistakenly takes the wrong baby home, prompting Lois to call him an idiot. Determined to prove to her that he's a responsible adult, Peter goes on a business trip to Chicago and returns as an intelligent, classy person.

After discovering his checks are actually a large size post-it pad, Peter demands he have access to the checking account. While at the bank, Peter & Lois discover that his first name is actually Justin, so Peter embraces his new partying “bro” lifestyle. Meanwhile, Joe arrests Glenn after he sleeps with an underage girl, which leads to an unexpected reunion.

Peter’s sister, Karen, decides to come for Thanksgiving and bullies Peter the same way Meg treats him. While Meg is at first amused, she later feels badly and decides to help Peter train to defeat his sister in a wrestling match. Meanwhile, to avoid overeating on Thanksgiving, Stewie and Brian decide to go on a cleanse, which Stewie takes one step too far.

Quagmire discovers the “dating” app Tinder, forcing Peter, Joe and Cleveland to intervene and save him from his soul-sucking hedonism. Meanwhile, Stewie finds out that he has scoliosis and learns the perks of his latest diagnosis

Peter and Louis find themselves with a golden opportunity to reconnect as a couple after Lois' parents get a nanny to take care of the children for them.

Peter and his friends are sick of forgetting the million-dollar business ideas they come up with while drinking, so they strap on Joe's police body cams to record their every move. Meanwhile, Quagmire is trying to come to terms with an unexpected family development.