Lois gets a job as the church organist, so the family decides to begin going back to church. When Stewie gets sick after receiving communion, the congregation becomes convinced that he has been possessed by the devil. While on the run, the family ends up in Texas, where Peter begins to fit right in with the cowboys, Stewie enters the "Little Miss Texas" pageant, and Chris and Meg sneak into George W. Bush's house.

Peter decides to grow a mustache, and after being mistaken for a fireman, ends up lending a hand when a fire breaks out at a local fast food restaurant. The owner gives him unlimited burgers as a thank you, but he eats too many and has a stroke. When Peter recovers, he vows to expose the fast-food company for what it really is, becoming friends with a genetically engineered cow along the way.

James Woods returns to seek revenge against Peter. James Woods finds Peter's wallet, which he lost at Barry Manilow concert, and procedes to steal Peter's identity, and his family. Peter decides to ruin James' career and image.

After buying a brain-damaged horse, which causes over $100,000 worth of damage, Peter participates in medical experiments to make some extra cash. One of the genes he is injected with turns him gay, which later results in him leaving Lois for another man. Although the family is crushed, they quickly realise the most important thing is that Peter is happy.

Peter learns from a psychic through a palm reading that he had a fascinating past life in the 17th century as Griffin Peterson, a dignified English gentleman who vied for the love of Lady Redbush in the newly founded American colony of Quahog.

Peter and the guys interview potential friends to fill the vacancy left by Cleveland. Meanwhile, Brian discovers that Quagmire hates him.

Peter, Joe, and Quagmire search for the source of a dirty joke.

Meg is enlisted to check in on Susie and Joe while Bonnie is away but she soon becomes a little too involved. Meanwhile, Stewie accidentally creates an evil twin.

While the Griffins are housebound during a hurricane, Brian ingests psychedelic mushrooms. He sees bizarre and unsettling things, and acts accordingly. Meanwhile, the rest of the family is bored and irritable, and Meg finally lashes out at Chris, Lois and Peter for all the crap they've given her.

The crossover starts on The Cleveland Show S03E02 The Hurricane (I). It continues on American Dad! S08E02 Hurricane! (III).

Peter and the guys take a stand against their wives and flee to the Deep South on a road trip. On their Deep South road trip, Peter and the guys earn a one-way ticket to jail, then decide to make a run for it.

After a night out, Peter, Joe, Brian and Quagmire awake in a hospital and discover that they don't remember anything and that the town has been deserted.

When Brian discovers that Carter Pewterschmidt’s pharmaceutical company is withholding the cure for cancer from the public in order to gain more profit, he and Stewie plot to expose the big secret that could change the world. Meanwhile, Quagmire reveals a hair-raising secret of his own.

When Peter, Quagmire and Joe visit the Harvard University campus, Quagmire accidentally marries a prostitute. In order to get out of his marriage, Quagmire pretends to be lovers with Peter.

When the owner of The Drunken Clam is killed, Peter and the guys must find a way to save the bar, after the bank threatens to close it. Meanwhile, Meg gets a part-time job at a funeral home.

When Peter and Quagmire discover that their singing voices create beautiful harmony together, they form a singing/songwriting team, in the vein of Simon and Garfunkel. However, tensions run high when fame gets to Peter’s head.

Chris is forbidden to see Jerome's daughter Pam, so when the kids run away together, Jerome and Peter must work together to find them.

Meg is thrilled to be recruited as a model, but it turns out to be for a very specific type of modeling: the foot-fetish industry. Meanwhile, Brian accompanies Stewie on an open-road adventure when Stewie decides he wants to experience life outside of preschool.

Peter claims he would beat Liam Neeson (guest voice Liam Neeson) in a fight, but when he is put to the test, he learns that winning is tougher than it seems. Meanwhile, Stewie becomes jealous when Lois decides to be a class mom and starts paying more attention to the other kids over him.

When Peter’s couch is stolen from his front lawn, the guys form a neighborhood watch group. While on duty, Peter sees someone trying to climb into Cleveland’s house and he shoots him. Peter is then arrested and charged with a hate crime. Meanwhile, Cleveland is touched when Peter finally admits to the accident, so he takes the fall for the crime and Peter is exonerated.

Meg begins working at a retirement community and starts stealing from the residents. Then Chris finds out and wants in on the heist. When the residents catch them, they blackmail them and force the thieves to listen to all of their boring stories.

Taylor Swift agrees to go to a homecoming dance with Chris after he asks her via online video. However, when she starts to fall for him, her music takes a hit. Meanwhile, Peter decides to try a new profession and sees firsthand what it's like to be an Uber driver.

Quagmire discovers the “dating” app Tinder, forcing Peter, Joe and Cleveland to intervene and save him from his soul-sucking hedonism. Meanwhile, Stewie finds out that he has scoliosis and learns the perks of his latest diagnosis

Peter becomes friends with a cool, handsome paramedic named Stryker Foxx. Wrapped up in his newfound "coolness," he soon dumps Quagmire, Joe and Cleveland.

Brian is smitten with a female show dog and enters a show dog competition in which the winner gets to breed her; Peter and Lois go to extreme measures to try to convince Chris that Arthur Valentine doesn't exist.

Stewie is surprised when he makes friends with another boy his age, but later taken aback when he learns that Stewie wasn't invited to his birthday party.

Stewie and Brian compete for the inheritance of a wealthy, older heiress. Meanwhile, Peter and Chris battle for Mr. Herbert's affection.

After Lois reads a new book on the joys of decluttering, she challenges the rest of the Griffins to throw anything out of the house that does not spark joy. While all starts out well, Lois soon takes the decluttering to a surprising extreme.

Peter gets himself arrested to avoid Lois' special Thanksgiving dinner; A secret that Stewie's been keeping from everyone is revealed.

Stewie's future life could not be going any better, living as a wealthy, old Mr. Burns-type man, until his retirement is interrupted by Brian, who brings news that Peter is dying.

Peter and Lois accidentally set up a cutaway gag together, which somehow transports them into the cutaway itself.

After attending a baseball game, Peter and Chris are inspired to start a memorabilia business. Meanwhile, Stewie tries to combat aging by getting plastic surgery, but ends up taking it too far.

When Peter and Quagmire accidentally switch underwear, they begin to mimic the other's behavior. Stewie and Doug agree to commit each other's murders.

An accident leaves Peter with a high-pitched voice, so Jesus coaches him into fending off the choir boys; Stewie is attracted to Lois' new masculine physique.

Peter attends a business conference in Atlantic City with Preston. Meanwhile, Stewie helps Chris prepare for his role in Adam West High's rendition of "Romeo and Juliet".

Peter and Chris finish last in a "Generation Gap" game at a carnival, forcing them to try to reconnect. Brian starts to date a carny, whom he can't break up with even after witnessing some of her crude habits.

When Peter gets a job as the new night watchman, he and the guys turn Pawtucket Brewery into an after-hours bar. Meanwhile, Stewie and Brian's plan to collect "lost dog" return money backfires when Brian is used for a dangerous TikTok stunt.

Winner of a Snapple contest, Lois uses her winnings to take Meg on a tropical vacation. Flaunting their wealth, the two are kidnapped. Meanwhile, Stewie and Brian undergo "friendship therapy."