When Mayor West is put on trial for murder, Brian is the lone holdout voting "not guilty," and he tries to persuade his fellow jurors that there's a reasonable doubt of the Mayor's guilt.

When Peter's mother dies, he befriends her longtime pal Evelyn, who tries to seduce him. In the meantime, Stewie feels despair upon dealing with the realities of death.

After running into Jesus at the Quahog Mall, Peter is stunned to discover that the Son of God is still a virgin. So, he enlists Quagmire and Cleveland to help him throw Jesus the best birthday ever by finding a way to help him become a man.

When Joe is trampled in a local running of the bulls and becomes a quadriplegic, the guys find it too difficult to hang around him. Meanwhile, Brian sleeps with a married woman, and when the husband returns home, he pretends to be the family’s new dog.

In an anthology episode, the cast reenacts three classic pieces of literature commonly taught in high school: "The Great Gatsby," "The Adventures of Huckleberry Finn" and "Of Mice and Men".

When Stewie receives a participation medal in his school's toddler games, he begins to question everything he has ever won. Meanwhile, Peter causes a fight between Lois' parents and must repair the damage he caused.