Peter decides to pursue his dream career as a knight.

Peter's jealously forces a trial separation; Stewie and Brian get glued together.

Viewer mail inspires three stories in which Peter loses his bones, the Griffins gain superpowers, and Peter and his friends appear as eight-year-old "Little Rascals."

"The Bachelorette" comes to Quahog and Brian is chosen to be a contestant. Brian does not like the show, but participates just to have a vacation only to wind up falling in love with the bachelorette. Meanwhile, Chris gets a nasty pimple on his cheek, which talks to Chris and likes to cause mischief.

The Griffin family decides to start their own restaurant, though have a hard time attracting customers. After Joe promises to help, Peter is excited at the fact of it becoming a local hangout for the police. However, things don't really turn out as hoped, and instead it begins to be popular with the handicapped. When Peter attempts to change the place, a sudden twist of irony quickly changes his mind.

Lois runs for mayor of Quahog, though she doesn't become the front-runner until she dumbs down her political views. Once in office, she becomes corrupted with the power that she now holds, and begins accepting bribes so that she can buy herself expensive things. Meanwhile, Peter comes to enjoy being the "first lady" of Quahog, and all of the perks that go along with it.

When Peter gets a pet parrot, he begins acting like a pirate. Peter accidentally kills the bird after raising hell through all of Quahog. Meanwhile, when Brian is visiting the vet, Chris falls in love with the intern, Anna.

After buying a brain-damaged horse, which causes over $100,000 worth of damage, Peter participates in medical experiments to make some extra cash. One of the genes he is injected with turns him gay, which later results in him leaving Lois for another man. Although the family is crushed, they quickly realise the most important thing is that Peter is happy.

With the help of an out-of-this-world remote control, Stewie and Brian travel through alternate universes, including a post-apocalyptic world and a parallel world run by dogs where humans are pets.

Brian gets a gig writing for a teen magazine about the average American girl, but when he starts trailing Meg for research he discovers that her desperate attempts at dating have led her to a guy in the slammer. When Brian tries to expose Meg’s secret to the family, he finds out that her boyfriend, Luke, has broken out of jail and has been hiding in the Griffin’s house.

Overwhelmed with financial troubles, Mort asks Peter and Quagmire to help him save his pharmacy. However, things take a turn for the worse when the trio decides to burn it down to collect insurance money

Peter and Chris go to fat camp where they cross paths with a serial killer who targets overweight kids; an album cover frightens Stewie.

Stewie meets a female version of himself and falls in love; Peter and Quagmire step up their friendship.

When city hall threatens to close Peter's business, he joins the Tea Party and campaigns to shut down the government.

Brian abuses Stewie's time machine and causes reality to run in reverse. So the two must work together to set things right before Stewie is “unborn.”

When the Griffins find themselves in a financial bind, Lois is forced to find a job of her own. She gets discovered by a "voiceover" talent agent named Randy, who actually runs an adult-only phone line and pays his employees generously. As Lois settles into her new gig, she hears Peter's voice on the other end of the line.

Peter grows frustrated when players on opposing teams continue to thank God after defeating his beloved New England Patriots football team, so he and the guys embark on a global quest to find God and ask Him to stop interfering with the outcome of professional football games.

Cleveland returns to town, but is instantly banned from spending time with Peter when Lois and Donna get into a big fight over parenting.

In a special hour-long crossover with The Simpsons, the Griffins meet the Simpson family when they end up in Springfield after their car is stolen. Stewie takes lessons in pranks and skateboarding from Bart, while Lisa discovers - to her annoyance - that Meg is as good at playing the saxophone as she is. Peter bonds with Homer as they locate the missing car, but then they fight after Peter loses his job when Pawtucket Patriot is revealed to be a copy of Duff Beer.

Peter's friends roast him. With his feelings hurt, he seeks refuge by befriending a group of gossipy women.

When Brian accidentally becomes a local hero, an old street pal, and now a successful millionaire dog, reaches out and tries to convince him to get neutered. Meanwhile, Lois gets a pixie cut against Peter's wishes, so Peter retaliates by trying to out-embarrass her.

Cooped up in a hotel room due to a big storm, the Griffins pass the time by reimagining three stories from the Bible.

When the family fails to help Lois with the Christmas shopping, she walks out on the family and the Griffins must try to save Christmas on their own.

Stewie gets a mail order bride from Ukraine and experiences domestic life. Meanwhile, Peter and Chris become addicted to free hotel breakfast buffets.

While at an old record store, Peter and the guys recount tales of three rock legends: Jim Morrison, Muddy Waters and Elton John.

In noir-style, Peter/Mac investigates the disappearance of Meg/Sister Megan.

After a Christmas tree lightning ceremony Brian crashes into Mayor West's nativity scene causing outrage.