When Senator Perrin makes his stand against the Rossum Corporation, Echo attempts to stop his expose. Adelle, and Topher begin to see what they are up against in the rival of Washington DC.

After her entanglements with Senator Perrin and the DC Dollhouse, Echo finds herself out in the world-at-large as she struggles to control her multiple memory downloads. Topher discovers the dangers of science that will have devastating effects on the future, while Adelle engages in a power struggle with Harding.

As his contract with the Dollhouse expires, Victor is released back into the world, where his military past threatens his future with Sierra. Meanwhile, Echo is deemed too dangerous and is sent into her worst nightmare.

In the year 2020, Echo and her surviving Dollhouse crew attempt to restore order to a devastating future world before mankind is eliminated.