In an emotionally charged trial John Adams defends the British sentries involved in the Boston Massacre who contend they were provoked into firing on the assembled crowd. John's success brings him offers of positions in the Massachusetts government. But after John Hancock rouses a crowd to tar and feather a representative of the British East India Tea Company and the British respond to the growing unrest with oppressive measures, John instead speaks against the British policies and chooses to represent Massachusetts in the Continental Congress.

After viewing the dead and wounded on the battlefield of Concord, John Adams takes up the cause of Independence. Frustrated by the caution of delegates from colonies that do not share Massachusetts plight, the inexperienced politician is abrasive, obnoxious and even insulting. But with the advice of Abigail and Ben Franklin he soon learns he has allies, to cultivate them, to bide his time and to seize opportunities. Following John's nomination, George Washington takes charge of the army and enjoys successes despite supply shortages. Back at home, Abigail and the children risk supporting the war effort in most tangible ways but find Mother Nature more threatening.

John Adams chaffs under the mantle of Vice President for its utter lack of authority and responsibility. Despite his abhorrence of the divisiveness of political parties John is drawn to the Federalist camp favoring a strong executive. Divisions even reach into the President's cabinet, exacerbated by war in Europe.

In retirement John Adams laments the perils of a long life; loss of loved ones and growing irrelevance. But out of tragedy John rekindles his broken friendship with Thomas Jefferson and lives to discuss John Quincy's ambitious presidential agenda with him.