An anesthesiologist who worked in a beauty clinic is discovered swinging from a rope in his two-story condo, but the investigation points to murder, not suicide. The case intensifies when it's learned that the doctor lost a patient the week before during routine plastic surgery and that the victim's husband believes she was killed.

A security guard is found dead after shots ring out at a rap star's concert and the CSIs must investigate. Rap star 10-Large won't talk to the police regarding the murder or why someone would try to kill him. But when evidence suggests that perhaps 10-Large's bodyguard was the intended target, the CSIs must look into the dangerous world of personal security. Meanwhile, Alexx gets the shock of her life when a supposed cadaver from a recent car accident wakes up in her morgue, suffering only from hypothermia.

The wife of a famous baseball player is brutally killed in her home and her philandering husband is charged with the crime. The jury on the case, as well as the accused and his defense, visits the house to examine the crime scene, but when the lights are dimmed, as they were when the victim was killed, and then turned back on, the ball player is found dead with a meat clever in his back and a note that reads "guilty." Now, as Horatio and the team find that the husband's defense team tampered with the crime scene, they must examine the evidence to find the couple's killers. Meanwhile, Horatio gets a call from Yelina, who tells him that her son, Ray, Jr., is missing.

When gang-related gunplay goes down in an emergency room, Horatio and the team must find the gang members responsible. The evidence suggests that an orderly in the hospital recognized the wounded gang member, who possibly killed one of the orderly's friends and alerted gang members to his location. However, the evidence doesn't match up and the CSIs discover that a cheating girlfriend, not gang retaliation, may be behind the shooting. Meanwhile, Ryan questions a mother in the emergency room after her story regarding her child doesn't add up.

An extreme skateboarder and videogame tester is found dead on a half-pipe platform used to program extreme skateboarding video games. The CSIs discover that he was wearing reflective sensors when he was killed, so the motion-capture device used to produce these videogames recorded the murder as it happened, but not the murderer. Now the team delves into the highly competitive world of videogame programmers and testers to find the killer.

A former high school football star is murdered at a reunion, the CSIs must find the killer. The victim was the big man on campus in high school and there are a lot of guests at the reunion with reasons to resent him all these years. Now, the team must investigate everyone, from the head cheerleader to the school misfit, to see who held a decade-old grudge big enough to kill. Meanwhile, Horatio and Delko arrive at a crime scene and discover that it's already been processed, leading Horatio to uncover further information about his brother possibly being alive.

The search of a missing 17-year-old girl, whose trip to Miami turns into an ongoing nightmare.

The CSI's are called out to investigate the murder of a young woman who was about to sign her divorce papers. Soon the husband turns out to be the ideal suspect. The only strange thing about the case is the murder weapon: a nailgun. The case becomes complicated when one of the CSI's is attacked when he returns to the crime scene and ends up in hospital.

When evidence shows that a series of murders is linked to organized crime, Horatio and the team are instead lead to a pair of film students who have screenplay that contains the details of the crimes.

The team is sent to investigate the death of a local celebrity, who is found murdered in her bathtub. The list of suspects includes her musician boyfriend, her assistant and her rival. The search for a young abducted girl is triggered, and Horatio tells Delko of Marisol and his plans.

The body of a local politician is found in an empty house. The entire neighborhood was upset that he was backing the use of eminent domain, allowing the government to force them out of their homes.

After Nick is found to have been killed with all the evidence pointing to Natalia as the killer the rest of the team has been sidelined by the Internal Affairs investigation. Horatio with the help of the night shift lab and Calleigh’s ex-boyfriend have to find the evidence to clear Natalia.

After a wealthy businessman is killed at a charity event the CSI's first suspect his wife who was hosting the event. The blood evidence is thought to belong to the wife or her two secret twin sisters but leads the investigators in another direction after the victim is not who they thought he was.

Strange events begin to happen as the CSI team tracks down a serial killer who killed during a solar eclipse.

Lifestyles of the rich and famous come under the CSI microscope when a wealthy family's nanny turns up dead.

As the first new medical examiner they have is shot, the CSIs learn the streets of Miami got more dangerous. Horatio must keep his team alive and restore order to his son's life. The clock runs out when one of their own is gunned down.

Calleigh and Eric are put in danger when a 200-foot crane crashes into a tall Miami building. This also destroys Horatio's best chances of catching a crime boss.

Horatio and the team go head-to-head with a defense attorney who may be involved in a murder cover-up.

When a reality star is murdered, the CSIs delve into the scandalous, sexy world of a TV dating show.