Horatio is quick on the scene when an armored truck carrying $3.2 million is robbed in a daring downtown heist. During the holdup, the driver is killed and Horatio guns down one of the two thieves. The other escapes with the loot, but the money turns out to be counterfeit. The team must figure out what happened to the bank's money before it was replaced with fake bills. Making the day even worse for Horatio, Yelina spies him with his niece and assumes the girl is his illegitimate child, not her own late husband's daughter.

The CSIs uncover a complex counterfeiting operation after a bellboy is found murdered at one of Miami's hottest hotels. The luggage that the deceased bellboy had been loading, as well as a heist of a special paper that money is printed on, leads the CSIs to uncover a complex counterfeiting operation. It's cruise season in Miami, which means that the population of Miami swells, giving the team even more suspects to the murder. Meanwhile, Calleigh must investigate when a woman goes missing, and is later found dead, after she and her husband attend a hot and flirty "friction" party.

Someone uses a laser light to blind a pilot and bring down a jet, which carries $1.2 billion in checks to be delivered to banks on the eastern seaboard. The crime scene evidence reveals a victim, a young fundraising socialite, who was inside the plane but killed prior to the crash. Now, although the team has little to work with since the victim's wealthy family is opposing an autopsy, Horatio must follow the money trail. Meanwhile, Calleigh works on the case with her ex-boyfriend, Detective Hagen, and their romantic history could cause problems for both of them.

Eric Delko is at the bank, following an ATM taking his debit card, when three robbers wearing ski masks rush in. Delko knows he can’t win against the three robbers but when one of them tries to rape a girl it ends in a shootout. The security tape leads them to Miami University and to the robbers next target and Horatio manages to arrest one of them. The trail leads to a videogame named “Urban Hellraisers” and when Ryan Wolfe starts playing it, it turns the similarities between the game and the actual crimes are very big. It’s up to the team to catch the robbers before they commit a crime much more serious than the last one.

The CSI team must try to find out who is trying to kill a young couple who are released from prison. The couple was made out to be “media darlings” and soon find that not everyone though of them as darlings. Calleigh must work with her ex-boyfriend to help solve the case.

In this thrilling season finale, the loss of one of their own is the first hit the lab will take. Getting back to the lab to process the evidence, they find it has been taken over by Federal Agents looking for stolen money from a previous case.

The dead body of a celebrity is found at an A-list party. They soon discover that the murder is linked to a “death pool,” where gambling occurs on an offshore ship. A counterfeit ring is also discovered where 100-dollar bills are produced in this 100th episode of CSI: Miami.