Sam and Dean investigate a series of mysterious drownings written off as suicides. They discover the spirit is an angry little boy with the power to travel through water who is taking revenge on certain town inhabitants for a dark secret buried long ago. Dean forms a bond with a young boy who seems to have the power of premonition.

While battling a demon, Dean is electrocuted, resulting in permanent damage to his heart and leaving him with only a couple of months to live. A despondent Sam searches desperately for a way to save his brother and believes he may have found an answer through a preacher who claims to heal the incurable. However, Dean and Sam discover that the preacher is getting help from the Grim Reaper who is trading one life for another he feels is less worthy.

Sam has a premonition in which a man is killed, but the murder is made to look like a suicide. Sam convinces Dean that they must investigate the case, but the two are puzzled when they fail to find anything that indicates that the death was supernatural in nature. That is, until they find out that Max, the reclusive son of the first victim, has been using his recently acquired power of telekinesis to kill the family members that once abused him. Sam also discovers Max's mother was killed by the same fiery demon that took his own mom.

John has realized where the demon will strike next and the Winchesters head there to stop the next killing. But Meg begins killing John's friends and demands the Colt or she'll keep going until everyone John knows is dead.

Dean and Sam investigate the death of a young college student who died in a car accident, but whose grave is now surrounded by a circle of dead plants.

Sam meets a woman who shares his ability to have visions, and she warns him that she has seen the future... where he dies in an explosion.

A fatal automobile accident from 1992 leaves an angry apparition haunting a remote stretch of highway, and Sam and Dean try to lay it to rest.

Dean is attacked by a Djinn... and finds himself in a new reality where his mother is still alive and a mysterious woman holds the key to everything.