The Sliders land on a world with little water and come to the aid of a mysterious young woman whose gift to find water is being exploited by a group of thugs.

On a world ruled by Egyptian culture, Quinn is used in a life-after-death experiment and thought dead. The others miss the slide when trying to save a woman from a sacrifice and become trapped in a pyramid with a big scarab.

Things don't look good for the Sliders when they slide to a world that's about to be eradicated by a rogue pulsar. Soon they discover that this world has been developing sliding technology and pool their resources with the U.S. government in a race to escape to a parallel Earth.

Quinn and Maggie return to her world with Earth Prime's coordinates stored in Jensen's timer. As Wade makes the final list for those who can slide to safety, Arturo races to modify the new timer to slide more people. Unfortunately for them, an unexpected danger lurks the base and one Slider will not make it to the next world.

Wade falls under the spell of a rock band's charismatic lead singer, who is really a vampire and looking to use Wade to get the timer. Meanwhile, the others try to track down Rickman.

The Sliders land on a world where California has been taken over by racists. Rembrandt is captured and placed in a prison camp used to turn non-whites into faceless slaves.