Friends in the early 1990s (Kenan Thompson, Forte, and Parnell) discuss the music video by pop stars Ariel (Andy Samberg) and Efrim (Tom Hanks), where we see the lyrics consist of constantly begging for their testicles not to be harmed, in a parody of Right Said Fred's "I'm Too Sexy" and C+C Music Factory's "Gonna Make You Sweat". Also, Fred Armisen plays the guitar player, Jorma Taccone appears as a backup dancer, and Amy Poehler and Maya Rudolph are women in the video.

New office employee Gary (Bill Hader) gets into a fight to the death with incumbent cubicle holder Steve (episode host Dane Cook). Jason Sudeikis appears as the boss and Andy Samberg, Will Forte, Fred Armisen, Kenan Thompson, Amy Poehler and Kristen Wiig are other employees cheering on the fight.

A fast food boss (Armisen) gives his employees (Forte, Matthew Fox, Poehler, Samberg, Thompson) a pep talk and has trouble controlling his anger until one of his employees (Forte) comes in late.

It originally was scheduled to air on the episode hosted by Matthew Fox (which explains his appearance), but ended up airing on the following episode hosted by Annette Bening.

A corporate executive (Rainn Wilson) leads a meeting to take ideas on how to save his failing company, and hears suggestions from an increasingly bizarre set of employees, including a gigantic turkey sub and Arcade Fire. Upon reaching the end of the meeting, Wilson receives a phone call, seemingly informing him that the office building is about to be blown up. Then, the office building explodes, killing all of them inside.

Neil Patrick Harris and the entire SNL cast perform the theme to Doogie Howser, M.D.. Harris wears a tuxedo while everyone else is dressed as Doogie Howser in blonde wigs, lab coats with a picture ID of Doogie on them, dress shirts, colorful ties, acid washed jeans, and Nike hi-tops (Armisen and Samberg wear green sunglasses as well). Harris plays keyboard; Wilson, Elliott, and Michaela Watkins play violin; Moynihan plays tuba; Thompson plays harp; Hader plays saxophone; Hammond plays trumpet; Wiig plays electric guitar; Sudeikis plays double bass; Forte plays drum kit; Armisen plays synthesizer; and Samberg plays an Akai MPC 2000XL drum machine. At the end of the performance, Harris sheds a single tear.

Samberg has some shots with none other than Pee Wee Herman (Paul Reubens). After beating Anderson Cooper (who appears as himself) over the head with a chair, Samberg and Pee-Wee are caught by the police, to which they escape by hitting the officer with a chair. When they return to Samberg's apartment, they come to an intervention with Cooper (bandaged up from being hit in the face with a chair by Pee-Wee and Samberg), Samberg's friends (Fred Armisen, Kristen Wiig, and Kenan Thompson), and Pee Wee's Playhouse friends Chairry, Pterri, and Conky, who plead with Andy and Pee-Wee never to be friends again. Andy and Pee-Wee reluctantly agree, and everybody celebrates the breakup with more shots.

A man (Samberg) and woman (Wiig) dressed in '70s-style clothing declare their love for each other in song. As the camera pulls back we can see that they are connected by their shared enormous afro. An unexplained man in janitor's clothing (Kenan Thompson) appears in between every verse and plays one riff on a strange instrument such as conch shell or didgeridoo. When the camera has pulled all the way back, revealing the full, massive afro, the couple invites the viewer to come to their wedding, whereupon the video is revealed to be a Save the Date. RSVP options "Yes" and "No" appear. "No" is clicked.