In the updated version of the popular 1990s series, landlady Sydney Andrews has made herself into the a central figure in the lives of all her tenants, especially David Breck, the son of her ex, Dr. Michael Mancini. Other tenents include publicist Ella Simms; Auggie Kirkpatrick, a sous chef; Lauren Yung, a medical student; and Jonah Miller, an aspiring filmmaker.

Jonah and Riley decide to head to Las Vegas to elope but the day doesn’t quite go as planned. Ella arranges a pitch meeting for Jonah with an important producer who is interested in buying his film. Meanwhile, Lauren calls David after she gets in trouble with one of her male clients and Auggie confesses his true feelings for Riley. Also, Michael gives David information about Sydney’ killer and Amanda bonds with Violet over Sydney, but of course Amanda has an ulterior motive in getting to know Violet.

Amanda fires Ella from WPK. However, not one to go out without a fight, Ella searches for anything to blackmail Amanda. Unfortunately for one of the ladies, the end result is worse than she could have ever imagined. Meanwhile, after attending a NYU reunion, Jonah asks Riley to reconcile and Lauren and David get back together but a jealous Morgan retaliates and puts Lauren’s life in jeopardy. Drew tries to stop Michael from performing a dangerous surgery, but Michael sets Drew up to get caught with drugs, causing Drew to be thrown out of ULA. Finally, Sydney makes a surprise appearance.