Veronica (Taylor Schilling) helps a patient cope after a terrifying experience on the operating table launches him into a crisis of faith. Meanwhile, she suspects that Mike (Diego Klattenhoff) has moved on and started dating again. Sonia (Jaime Lee Kirchner) tries to track down the next of kin for a young patient after a car accident, but instead uncovers a terrible secret that will change the girl’s life forever. And Chloe (Michelle Trachtenberg) mediates a bitter family feud when her patient’s children can’t agree on a course of treatment for their dying father. James Tupper, James Le Gros, and Guillermo Diaz also star.

Veronica has her hands full when a group of promiscous college students is admitted to the hospital with meningitis and their love triangle has the Mercy staff comparing them to Veronica's own love life. Meanwhile, Chloe helps with wedding plans when a bride-to-be comes in with a simple flu but receives a much more serious diagnosis. Sonia has to deal with a hand transplant patient who wants his donor hand amputated after discovering it belonged to a pedophile and Dr. Sands gets a surprise visit from his sister.

A newlywed cancer patient is in a risky treatment and Chloe struggles to help her husband. Meanwhile, a man wakes up after tn years in a coma and he decides to confront the love of his life, helping Veronica to take action in her own love life. Meanwhile, Sonia gets a taste of how rich people live when she has a wealthy and eccentric patient to care for.