Piper falls for the ghost of a recently murdered man who needs her help. Meanwhile, Phoebe works as a psychic to help others and make money for Prue's birthday present, and Prue discovers a devastating betrayal.

When Phoebe has a premonition of Prue being stabbed to death, it coincides with a warrior coming to town in order to kill the eldest sibling witch as he did to the sisters' great-great-great-aunt.

The sisters are about to go on a relaxing weekend getaway to Cabo, when a mortally wounded Leo shows up and asks for their help to save a young woman who's being chased by a darklighter. Desperate to save Leo, Piper casts a spell that swaps their powers, however in doing so, she accidentally swaps the powers of Prue and Phoebe as well. Meanwhile, pressed by an Internal Affairs investigation Andy decides to leave his job in order to protect Prue's secret from being exposed.

The sisters discover that Phoebe is psychically linked, through her powers, to a man-killing demon known as a 'Succubus.' In order to lure the Succubus to the sisters, Prue casts a spell, which turns her into a man. Meanwhile, Piper discovers from a video tape at the dating service that their new neighbour, Dan, is interested in her.

The sisters must find a way to vanquish a ghost who is intent on killing all of the men in a family line, including the last male, a baby.

A group of three elderly witches, one of them close friends of the Halliwells' grandmother, summon a demon to restore their youth. However, in return, the demon wants the powers of the Charmed Ones.