A family weekend vacation to a casino turns into an ordeal in the desert for Hal, Reese and Malcolm, who wander onto an artillery range. Francis sneaks home, but has no one to play with.

Lois' estranged parents, Ida and Victor, pay the family a visit. Right away, trouble starts brewing. Victor bonds with Reese, Ida gets Malcolm into a fight, and Dewey is haunted by childhood memories of his inattentive grandparents.

Hal is inadvertently responsible for a toxic chemical spill that forces a neighborhood evacuation; Malcolm deals with being grounded even in the emergency shelter; Francis suffers through a date with a geeky 12-year-old.

In an effort to contribute to society and to make her boys useful at the same time, Lois "volunteers" Malcolm, Reese and Dewey for charity work at a local church. The boys are assigned to sort giant piles of donated clothing, game, appliances etc. Initially irritated at their new task, they realize the donated stuff is a lot nicer than their own possessions, and they begin swapping out their old stuff with the second-hand items. The boys soon make a enterprise out of their charity assistance, going as far as to sell things to the neighborhood kids - that is until Hal finds out. Meanwhile, Francis must come to grips with the fact his fabulous job in Alaska is not quite what he expected.

Trouble finds Reese at his new fast-food job; a new Krelboyne tutors Malcolm; Hal and Lois sabotage Dewey's plan to get a dog.

After joining the basketball team at school, Malcolm soon finds himself under the coach's skin due to his constant complaining, which eventually gets him kicked off the team. Determined to put an end to his horrible habit of talking before he thinks, Malcolm starts "holding his tongue" which solves all the problems with his coach, girlfriend, and parents, but it ends up causing more stress than before. Meanwhile, Hal takes up speed walking and is desperate to be the best while Reese gets Craig to take him and Allison to a concert and almost ruins his date.

On a visit to Francis' dude ranch Hal can't help being disappointed in Francis' success, Reese and Malcolm fear Francis has turned into an overly responsible grownup, and Gretchen punishes Dewey for breaking a valuable doll.

With the arrival of their fifth child, Lois and Hal search for a "creative" daycare solution.

No one wants to tell Stevie his parents are getting a divorce, until Reese spills the beans.

Malcolm gets his tongue pierced and needs to hide it for a month. While Lois' mother, Ida, comes and annouces that she will marry a rich Chinese Man that she met on a cruise. Malcolm gets complications when his tongue ring gets infected, rendering him unable to say "S's" and he discovers that Ida has been drugging her fiancé with opiates and mood enhancers. When Lois and Hal confront Ida, she drugs them with free food. But luckily, the fiancé misses a drug treatment, and realizes that Ida is a terrible woman and he leaves her at the altar. Malcolm is punished for his tongue piercing. Meanwhile at the ranch, Otto decides to hire a murder mystery acting troup, but it all turns out badly.

Malcolm and Reese plot revenge after they realize their teenage neighbor has tricked each of them into believing the other is gay. Meanwhile, Hal, tired of competing with a neighbor who always outdoes his Christmas decorations, decides to create his own "holiday" to decorate his house for - Pearl Harbor Day.

When Lois finds renewed energy with orthotic inserts for her shoes, Hal fears she will not look to him for support anymore and plots to destroy the inserts. A former female army buddy of Reese's comes to their house for a visit. But she gets defensive when Reese thinks they are way more than just friends and comes intact to the idea of trying to sleep with her.