When Audrey and Walter go out of town for spring break they leave Drake, Josh, and Megan at home by themselves. When they are at the Premiere they overhear a couple saying that they don't have a place to stay. Drake and Josh take advantage of this opportunity and say that their vacant house is a hotel. Meanwhile, Megan is attempting to get Drake and Josh to treat her like a guest.

It's the time for the Science Fair. Josh is confident that he'll win first prize, until Mindy Crenshaw returns! Josh comes in second like every year, but he turns out to have a change of heart. After the Science Fair, he develops a liking of Mindy who also has a liking of him. Right before they know it, they're boyfriend and girlfriend!

When Walter is always coming home late and talking to another woman, Drake and Josh believe Walter is cheating on Audrey and they start snooping. Drake and Josh try all types of plans to keep them together.

After Helen has eye surgery she asks Drake and Josh to help her around her house. When Drake sees that she has a hot tub, a plasma screen TV, and a dancing machine, he takes advantage of Helen's blindness to use all her cool stuff.

Josh nabs a student teaching job in Megan’s classroom where Drake discovers an amazing kid drummer. But when the class revolts against teen taskmaster Josh, Drake rushes in to help Megan discredit him -- perchance to snare the drummer for his band.

Mindy tells Josh that she loves him and Josh slams the door in her face and runs to Drake, but Drake tells Josh that she is just trying to distract him so she can win the Science Fair.

Drake teases Josh that he can't get girls. So, Drake and Josh make a bet to see how many girls each of them can date in just one week. The rules are, every date must last at least one hour, you can't date someone you already know, and you can't date the same person twice.

Drake and Josh meet, "The Great Doheny", and find out that he relies on his new friends a little too much because he has lost everything including his career. In an attempt to get his career back for him, Drake and Josh find themselves in a tough situation.

Drake has taken advantage of Josh for the last time and Josh decides that he is done dealing with Drake. Drake says he's fine with this, but when Josh's life improves and Drake's goes down the drain this rocker begins crooning a different tune.