Atlanta lawyer Ben Matlock takes on the high profile case of a television reporter accused of murdering his former wife. The case is complicated when his daughter Charlene develops feelings for the accused killer.

Matlock agrees to defend Vanessa Douglas when she's accused of murdering Stephen Cassidy, and author who destroyed a political families ambitions with a tell-all book. When Matlock realises his client is indeed guilty of the murder she is charged of committing, he sets up a plan to implicate her best friend, Sarah, with the crime, knowing that Vanessa will not let her friend take the blame for something she did.

With Angela's help, Conrad tries to track down an informer they believe holds the key to Sam Chandler's murder.

Serial killer Jeffrey Speidel strangles his victims. When Matlock gets inovlved in the case, Speidel makes a point of turning Matlock into his next target...his goal is to ruin Matlock publicly before killing him.

Matlock is the unlikely witness when a boat blows up killing Judge Michael Sterns. Had it not been for Ben's sea-sickness, he would have been on the boat. Convinced that someone was out to get him and not Judge Sterns, Matlock, Cliff and Jerri take a look through some of Ben's old cases to find out who did it, and Matlock takes on the case of the man accused of the crime, a former lawyer who had been disbarred for jury tampering exactly five years earlier.