The Medici family dominated politics and the economy in Renaissance Florence. To break the Medici influence, the old-established Pazzi family attempts to assassinate brothers Giuliano and Lorenzo de Medici. They succeed only partially, leading to the capture of the perpetrators and a search for the conspirators. In a present-day investigation, Florence Kasumba together with historians such as Marcello Simonetta gathers clues from medicine, psychology, and art history.

In the summer of 1483 two boys reside in the Tower of London while the elder, aged 12, awaits crowning as the King of England. But doubts about the boy's right of succession result in his uncle receiving the crown, after which the two boys disappear. What happened to them? A cold case from the age of the knights in England, in which numerous new clues have been found in recent years.