Lilly investigates the 1964 murder of a 17-year-old girl who was sent by her parents to a home for unwed mothers, where she gave birth to a girl. The next day the teen was killed. The case is reopened when the victim's daughter comes forward, having just learned that she was adopted and that her biological mother was slain.

When the victim's younger sister comes looking for her, the team re-opens the 2006 case of a missing Amish girl who was murdered while she was in Philadelphia experiencing the Amish rite of passage called "rumspringa".

The team re-opens the 1989 case of an unidentified Jane Doe when she dies in the hospital, after being comatose since the day she was shot 18 year ago.

The team re-opens the 1963 case of teenage girl who was then thought to have committed suicide. Now, new evidence leads them to believe the girl might have been murdered for acting and dressing like a boy.

The team re-investigates the suspected 2007 murder of a bride-to-be who was kidnapped on the day of her engagement party. Lilly and Scotty travel to West Virginia to escort the prime suspect to Philly, and on their way back, they hear his side of the story.

The 1978 death of a teen roller skater who was found in a ravine is reinvestigated when a new witness comes forward.

The team re-investigates the 1988 murder of a young TV reporter. Previously unseen news footage suggests she was on the verge of breaking a huge story about the unethical practices of a plastics company.

The 2004 murder of a teen at a juvenile detention center is investigated. The boy was wrongly sent to the facility and was killed before Valens could get him released. Meanwhile, Lilly reconnects with former flame Eddie Saccardo, a narcotics officer.

The 1999 death of a high-school debate champion, which was originally ruled a suicide, is investigated after new evidence suggests he was murdered. The probe reveals the victim received a scholarship at a top private school and died shortly after losing a debate at the competitive campus.