Brain uses an enlarging ray to make himself and Pinky four hundred feet tall. With Pinky dressed as a Gollyzilla, Brain stages a fight to make himself look like hero. But then the real Gollyzilla shows up.

The Brain hatches a plan to take over the world by using static electricity to shock the world into submission. Unfortunately he needs several billion dollars to build a giant clothes dryer. Pinky and the Brain head to Island X where they set up a fake country and hope to get a giant foreign aid loan from the United States.

In Victorian England, the Brain realizes that he can take over the world by becoming president of the "Pompous Explorers Club". since the position usually leads to the Prime Ministership of England. In order to become president of the club, he must make it around the world in seventy-nine days.

In their latest plan, Pinky and Brain try to take over the steel mills in Pittsburgh, Pennsylvania by pretending to be a part of an endangered species called the Mousealopes.

After getting a glimpse of his future, Brain abandons his attempts to take over the world and gets a job as a ski instructor.

To save his Las Vegas casino, Brain works as a lounge singer.

Mr. Itch offers Brain control of the world in exchange for his soul, but Brain refuses. In a shocking twist, Pinky sells his soul to make it happen and Brain soon decides to get his friend back.

Brain takes control over aquatic mammals for his latest plan and Pinky falls for a female sea lion.

Brain tries to become a national hero by taking down a tobacco company.

Brain enters Pinky's family in a contest to win $25,000.

As he prepares his plan for world domination, Brain goes to work teaching rebellious students.

Pinky and Brain masquerade as a mother and child star respectively to get money needed for the next plan.

Inspired by legends of the past, Brain tries to create a legend about himself to gain world acclaim.