Brain hatches a plot to hypnotize people, but he needs white crab meat to succeed. In order to get the crab meat, he takes a submarine to the wreck of the Titanic. Unfortunately, the CIA spots his sub and orders its destruction.

In Victorian England, the Brain realizes that he can take over the world by becoming president of the "Pompous Explorers Club". since the position usually leads to the Prime Ministership of England. In order to become president of the club, he must make it around the world in seventy-nine days.

Brain plans to melt the ice caps with the Hubble Space Telescope once he buys everything higher than the 39th floor.

Brain tries to get all the people off Earth onto his paper mache creation, Chia Earth.

Brain makes a tearjerker movie to make the world sad enough to make him leader.

Brain enlists the aid of beavers to gain control over the flow of rivers.

The mice make a series of comedy films and hit the big time.

Pinky and Brain have a new companion, Larry, but their newest plan just doesn't seem to pan out.

In their latest plan, Pinky and Brain try to take over the steel mills in Pittsburgh, Pennsylvania by pretending to be a part of an endangered species called the Mousealopes.