Jim awakens one morning to find that his cranium has more than doubled in proportion. Initially embarrassed, it takes Jim nearly a week to leave his apartment, and his first stop is a head specialist. But good Dr. Axel can offer no solid answers, so an irritated Jim heads out the door for home. On his way, he's cornered by a gang of thugs, who have absolutely no idea what's awaiting them. Jim's head splits in two and out jumps a little purple alien who attacks them. After beating up the aggressors, the alien pops back into Jim's head, which seals up behind him. Dumbfounded, Jim heads home and interrogates the alien. Turns out his name's Roy, and he's on a mission to save the Earth from a parasitic alien named Gork. Dr. Lucas Elliott, a disgruntled FBI agent, catches the thugs telling their story on Eye Witness News, and begins his pursuit of Jim.

Jim had forgotten that he had set up a date with Madelyn, which Roy encourages him to keep.

Jim awakens to find that Madelyn has been possessed by Gork. Roy explains that the Gork race has made plans to invade the heads of Earthlings, and he came to Earth with a machine that could stop the invasion -- but it was broken into five pieces and scattered across the planet. Meanwhile, Dr. Elliott bursts in with his cronies to interrogate Dr. Axel. He tells of his childhood encounter with a Gork, then proceeds to kidnap the head specialist.

Roy spies the first piece of the anti-invasion machine lodged in the face of the Statue of Liberty. Roy hops on the Staten Island Ferry to retrieve the piece, but he finds himself hunted by sightseers who think he's an alien California Raisin. Meanwhile, Jim goes to a meeting of ""human anomalies"" and befriends the group -- but Jim and Roy's telekinetic link cuts their meeting short when Jim receives a cry for help. Jim enlists the anomalies' aid to help him save Roy from the angry mob.

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Dr. Elliott finds that the tables have turned – he's now the captive strapped to a table. Jim and his friends try to develop the anti-invasion machine without the orb, and soon find that they're running out of time as the Earth is bombarded with Gorks. At the last minute, they get the machine working and thwart the attempts of the parasitic race to take over the world.

An alien bearing a great resemblance to Roy breeched “the security of Technology Incorporated Laboratories and absconded with a container of dangerous experimental energy” (or anti-matter). Pasquale Mendoza alerts Jim and Roy to these events when he comes knocking, assuming that it was Roy who was responsible for the theft… but soon Jim and Roy spot another man with an unusually large cranium – which contains Roy’s baby brother, Mark. Mark is supposed to deliver the anti-matter to a race of nasty, green, humanistic aliens who need the substance for fuel, but a botched transaction on the moon leaves Roy as a hostage to the nasty aliens.