Dr. Craig ""Huff"" Huffstodt is a Los Angeles psychiatrist whose life and career is sent reeling when a tragedy occurs in his office. Huff's nurturing nature is also tested at home as he endures and deals with the conflicting personalities and small insanities within his own family.

Huff is forced to defend himself and his practice in front of a Medical Board hearing, with his reckless best friend and attorney Russell by his side. As if this weren't enough, Huff is besieged by Melody Coatar, a dangerously belligerent bipolar patient and is informed that he's being sued by a patient's parents.

Huff still feels guilty and angry, and so do his family and friends, about his potentially fatal fight with his best friend, Russell. He Beth's mother is dying and Beth is having a difficult time dealing with it. Izzy and Byrd have become estranged from the family. Meanwhile, Russell takes on a troubled new client, Dauri Rathbun.

Huff begins his search for Teddy in Mexico, but cannot find him. He ends up being forced to ask Russell, whom he nearly killed and who wants to have nothing to do with him, for help in locating his brother before something drastic happens. Meanwhile, Beth finds that Madeline has taken a turn for the worse and does not know what to do.

Huff decides to help out Russell once again. Izzy finally decides to visit Teddy. Beth chooses to tell Alec that she thinks of him only as a friend. Byrd gets upset by all his family's latest actions.