Ed, Danny, and Mike combine forces with the investigative team of Dr. Jordan Cavanaugh and Det. Woody Hoyt to solve the murder of a high-stakes gambler. The mystery intensifies when it appears that the gambler's wife may not be the only woman who wants him dead. Meanwhile, Snoop Dogg is trying to convince Delinda to allow the Montecito to be the site of his next music video. Elsewhere, Ed must deal with the demands of his wife Jillian, who has moved into the Montecito while their house is being renovated.

The crossover starts on Crossing Jordan S04E07 What Happens in Vegas Dies in Boston (I).